About the Authors
- Hendrik P. N. Scholl
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Contributed equally to this work with: Hendrik P. N. Scholl, Anthony T. Moore, Robert K. Koenekoop
* E-mail: hscholl1@jhmi.edu
¶‡ These authors are shared first authors on this work.
Affiliation Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States of America
- Anthony T. Moore
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Contributed equally to this work with: Hendrik P. N. Scholl, Anthony T. Moore, Robert K. Koenekoop
¶‡ These authors are shared first authors on this work.
Affiliations Moorfields Eye Hospital and Institute of Ophthalmology, University College London, London, United Kingdom, Dept. of Ophthalmology, University of California San Francisco, San Francisco, CA, United States of America
- Robert K. Koenekoop
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Contributed equally to this work with: Hendrik P. N. Scholl, Anthony T. Moore, Robert K. Koenekoop
¶‡ These authors are shared first authors on this work.
Affiliation McGill University Health Centre, Montreal, Quebec, Canada
- Yuquan Wen
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Affiliations Retina Foundation of the Southwest, Dallas, TX, United States of America, Baylor Visual Function Center, Baylor University Medical Center, Dallas, TX, United States of America
- Gerald A. Fishman
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Affiliation Chicago Lighthouse, Pangere Center for Inherited Retinal Diseases, Chicago, IL, United States of America
- L. Ingeborgh van den Born
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Affiliation Rotterdam Eye Hospital and Ophthalmic Institute, Rotterdam, The Netherlands
- Ava Bittner
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Affiliations Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States of America, Nova Southeastern University, College of Optometry, Fort Lauderdale, FL, United States of America
- Kristen Bowles
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Affiliations Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States of America, College of Optometry, University of Houston, Houston, TX, United States of America
- Emily C. Fletcher
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Affiliations Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States of America, Gloucester Royal NHS Foundation Trust, Gloucester Royal Hospitals, Gloucester, United Kingdom
- Frederick T. Collison
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Affiliation Chicago Lighthouse, Pangere Center for Inherited Retinal Diseases, Chicago, IL, United States of America
- Gislin Dagnelie
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Affiliation Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States of America
- Simona Degli Eposti
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Affiliation Moorfields Eye Hospital and Institute of Ophthalmology, University College London, London, United Kingdom
- Michel Michaelides
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Affiliation Moorfields Eye Hospital and Institute of Ophthalmology, University College London, London, United Kingdom
- David A. Saperstein
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Affiliations Vitreoretinal Associates of Washington, Seattle, WA, United States of America, QLT Inc., Vancouver, Canada
- Ronald A. Schuchard
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Affiliations QLT Inc., Vancouver, Canada, Stanford Univ School of Medicine, Palo Alto, CA, United States of America
- Claire Barnes
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Affiliations QLT Inc., Vancouver, Canada, VA Palo Alto Health Care System, Palo Alto, CA, United States of America
- Wadih Zein
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Affiliation Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, MD, United States of America
- Ditta Zobor
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Affiliation Institute for Ophthalmic Research, Center for Ophthalmology, University of Tübingen, Tübingen, Germany
- David G. Birch
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Affiliations Retina Foundation of the Southwest, Dallas, TX, United States of America, Ophthalmology, UT Southwestern, Dallas, TX, United States of America
- Janine D. Mendola
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Affiliation McGill University Health Centre, Montreal, Quebec, Canada
- Eberhart Zrenner
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Affiliation Institute for Ophthalmic Research, Center for Ophthalmology, University of Tübingen, Tübingen, Germany
- RET IRD 01 Study Group
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¶Membership of the RET IRD 01 Study Group is listed in the Acknowledgments.
Competing Interests
The authors have the following interests: This study was sponsored by QLT Inc., the developer of QLT091001. QLT owns and licenses certain intellectual property rights with respect to QLT091001. Drs. Scholl, Moore, Koenekoop, Fishman, Bittner, Dagnelie, Saperstein, Schuchard, Barnes and Birch served as paid consultants for QLT Inc. Dr Saperstein has an equity stake in Retinagenix (licensory to QLT of certain intellectual property rights relating to QLT091001) and is an inventor on patents directly involved with the technology. Dr. Moore is the Chairman of the DSMB of the gene therapy trials of Sanofi and Oxford Biomedica. Dr. Birch is on the DSMC of the gene therapy trial of Sparks. Grants to investigators at Johns Hopkins University are negotiated and administered by the institution (such as the School of Medicine) which receives the grants, typically through the Office of Research and Administration. Individual investigators not named above who participated in the sponsored project were not directly compensated by the sponsor but may have received salary or other support from the institution to support their effort on the project. There are no other patents, further products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Performed the experiments: HPNS ATM RKK YW GAF LIvdB AB KB ECF FTC GD SDE MM WZ DZ DGB JDM EZ. Analyzed the data: HPNS ATM RKK YW GAF LIvdB AB KB ECF FTC GD SDE MM DAS RAS CB WZ DZ DGB JDM EZ. Wrote the paper: HPNS ATM RKK YW JDM DGB EZ.