About the Authors

Mari Kojima

Contributed equally to this work with: Mari Kojima, Hiroaki Takehara

Affiliation Department of Bioengineering, School of Engineering, The University of Tokyo, 2-11-16, Yayoi, Bunkyo-ku, Tokyo, Japan

Hiroaki Takehara

Contributed equally to this work with: Mari Kojima, Hiroaki Takehara

Affiliation Department of Bioengineering, School of Engineering, The University of Tokyo, 2-11-16, Yayoi, Bunkyo-ku, Tokyo, Japan

Takanori Akagi

Affiliation Department of Bioengineering, School of Engineering, The University of Tokyo, 2-11-16, Yayoi, Bunkyo-ku, Tokyo, Japan

Hirofumi Shiono

Affiliation Nikon Corporation, 2-15-3, Konan, Minato-ku, Tokyo, Japan

Takanori Ichiki

ichiki@bioeng.t.u-tokyo.ac.jp

Affiliation Department of Bioengineering, School of Engineering, The University of Tokyo, 2-11-16, Yayoi, Bunkyo-ku, Tokyo, Japan

Competing Interests

TI and HS are co-inventors for a JP patent #5608555, 'A micro-chamber sheet and a cellular activity measurement device (in Japanese)', filed by The University of Tokyo and Nikon Corporation. MK, HT, HS and TI are co-inventors for a JP patent #5753735, 'A micro-reactor device, fabrication process of the device and measurement method of cellular activity' (in Japanese)', filed by The University of Tokyo and Nikon Corporation. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TI. Performed the experiments: MK HT. Analyzed the data: MK HT TA. Contributed reagents/materials/analysis tools: HS TI. Wrote the paper: MK HT TI.