First-In-Class Small Molecule ONC201 Induces DR5 and Cell Death in Tumor but Not Normal Cells to Provide a Wide Therapeutic Index as an Anti-Cancer Agent

Joshua E. Allen; Roslyn Crowder; Wafik S. El-Deiry

doi:10.1371/journal.pone.0143082

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Open Access

Peer-reviewed

Research Article

First-In-Class Small Molecule ONC201 Induces DR5 and Cell Death in Tumor but Not Normal Cells to Provide a Wide Therapeutic Index as an Anti-Cancer Agent

Joshua E. Allen,

Affiliation Oncoceutics, Inc., Philadelphia, Pennsylvania, 19103, United States of America
⨯
Roslyn Crowder,

Affiliation Department of Biology, Stetson University, DeLand, Florida, 32723, United States of America
⨯
Wafik S. El-Deiry

* E-mail: wafik.eldeiry@gmail.com

Affiliation Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Oncology and Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111, United States of America
⨯

First-In-Class Small Molecule ONC201 Induces DR5 and Cell Death in Tumor but Not Normal Cells to Provide a Wide Therapeutic Index as an Anti-Cancer Agent

Joshua E. Allen,
Roslyn Crowder,
Wafik S. El-Deiry

Published: November 18, 2015
https://doi.org/10.1371/journal.pone.0143082

About the Authors

Joshua E. Allen

Affiliation Oncoceutics, Inc., Philadelphia, Pennsylvania, 19103, United States of America

Roslyn Crowder

Affiliation Department of Biology, Stetson University, DeLand, Florida, 32723, United States of America

Wafik S. El-Deiry

* E-mail: wafik.eldeiry@gmail.com

Affiliation Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Oncology and Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111, United States of America

Competing Interests

Joshua Allen is an employee and stockholder of Oncoceutics, Inc., and Wafik El-Deiry is a stockholder of Oncoceutics, Inc. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JEA RC WSED. Performed the experiments: JEA RC. Analyzed the data: JEA RC. Contributed reagents/materials/analysis tools: JEA RC WSED. Wrote the paper: JEA WSED.

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Cancer treatment
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Lung and intrathoracic tumors
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Cancers and neoplasms
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Dogs
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Toxicology
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Apoptosis
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Cell death
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