About the Authors

Sirpa Koskela

Koskela.Sirpa.M@student.uta.fi

Affiliation Department of Internal Medicine, Tampere University Hospital, Tampere, Finland

Outi Laine

Affiliations Department of Internal Medicine, Tampere University Hospital, Tampere, Finland, School of Medicine, University of Tampere, Tampere, Finland

Satu Mäkelä

Affiliations Department of Internal Medicine, Tampere University Hospital, Tampere, Finland, School of Medicine, University of Tampere, Tampere, Finland

Tanja Pessi

Affiliations School of Medicine, University of Tampere, Tampere, Finland, Science Centre, Pirkanmaa Hospital District, Tampere, Finland

Sari Tuomisto

Affiliations School of Medicine, University of Tampere, Tampere, Finland, Fimlab Laboratories Ltd, Tampere, Finland

Heini Huhtala

Affiliation School of Health Sciences, University of Tampere, Tampere, Finland

Pekka J. Karhunen

Affiliations School of Medicine, University of Tampere, Tampere, Finland, Fimlab Laboratories Ltd, Tampere, Finland

Ilkka Pörsti

Affiliations Department of Internal Medicine, Tampere University Hospital, Tampere, Finland, School of Medicine, University of Tampere, Tampere, Finland

Jukka Mustonen

Affiliations Department of Internal Medicine, Tampere University Hospital, Tampere, Finland, School of Medicine, University of Tampere, Tampere, Finland

Competing Interests

Sari Tuomisto and Pekka J. Karhunen are employed by Fimlab Laboratories. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SK OL SM TP ST HH PK IP JM. Performed the experiments: TP ST. Analyzed the data: SK HH SM OL JM. Contributed reagents/materials/analysis tools: TP ST PK SM JM. Wrote the paper: SK OL SM JM IP. Participated in revising the manuscript critically: SK OL SM ST TP IP JM. Produced the figure: IP HH. Read and approved the final manuscript: SK OL SM TP ST HH PK IP JM.