Absolute Quantification of Endogenous Ras Isoform Abundance

Craig J. Mageean; John R. Griffiths; Duncan L. Smith; Michael J. Clague; Ian A. Prior

doi:10.1371/journal.pone.0142674

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Open Access

Peer-reviewed

Research Article

Absolute Quantification of Endogenous Ras Isoform Abundance

Craig J. Mageean,

Affiliation Division of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3BX, United Kingdom
⨯
John R. Griffiths,

Affiliation Cancer Research UK Manchester Institute, University of Manchester, Manchester, M20 4BX, United Kingdom
⨯
Duncan L. Smith,

Affiliation Cancer Research UK Manchester Institute, University of Manchester, Manchester, M20 4BX, United Kingdom
⨯
Michael J. Clague,

Affiliation Division of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3BX, United Kingdom
⨯
Ian A. Prior

* E-mail: iprior@liv.ac.uk

Affiliation Division of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3BX, United Kingdom
⨯

Absolute Quantification of Endogenous Ras Isoform Abundance

Craig J. Mageean,
John R. Griffiths,
Duncan L. Smith,
Michael J. Clague,
Ian A. Prior

Published: November 11, 2015
https://doi.org/10.1371/journal.pone.0142674

About the Authors

Craig J. Mageean

Affiliation Division of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3BX, United Kingdom

John R. Griffiths

Affiliation Cancer Research UK Manchester Institute, University of Manchester, Manchester, M20 4BX, United Kingdom

Duncan L. Smith

Affiliation Cancer Research UK Manchester Institute, University of Manchester, Manchester, M20 4BX, United Kingdom

Michael J. Clague

Affiliation Division of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3BX, United Kingdom

Ian A. Prior

* E-mail: iprior@liv.ac.uk

Affiliation Division of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3BX, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IAP MJC DLS. Performed the experiments: CJM. Analyzed the data: CJM IAP. Contributed reagents/materials/analysis tools: JRG DLS. Wrote the paper: CJM MJC IAP.

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Carcinogenesis
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Ras signaling
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Colorectal cancer
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Heterozygosity
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Protein abundance
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Serine proteases
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Arginine
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Oncogenic signaling
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