About the Authors

Yuri Miura

Contributed equally to this work with: Yuri Miura, Noritaka Hashii

Affiliation Research Team for Mechanism of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

Noritaka Hashii

Contributed equally to this work with: Yuri Miura, Noritaka Hashii

Affiliation Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, Tokyo, Japan

Hiroki Tsumoto

Affiliation Research Team for Mechanism of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

Daisuke Takakura

Current address: Graduate School of Medical Life Science, Yokohama City University, Kanagawa, Japan

Affiliation Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, Tokyo, Japan

Yuki Ohta

Current address: Graduate School of Medical Life Science, Yokohama City University, Kanagawa, Japan

Affiliation Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, Tokyo, Japan

Yukiko Abe

Affiliation Center for Supercentenarian Research, Keio University School of Medicine, Tokyo, Japan

Yasumichi Arai

Affiliation Center for Supercentenarian Research, Keio University School of Medicine, Tokyo, Japan

Nana Kawasaki

Current address: Graduate School of Medical Life Science, Yokohama City University, Kanagawa, Japan

Affiliation Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, Tokyo, Japan

Nobuyoshi Hirose

Affiliation Center for Supercentenarian Research, Keio University School of Medicine, Tokyo, Japan

Tamao Endo

endo@tmig.or.jp

Affiliation Research Team for Mechanism of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

SONIC (Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians)

SONIC membership is provided in the Acknowledgments.

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TE YM N. Hashii. Performed the experiments: YM N. Hashii DT YO Y. Abe. Analyzed the data: YM N. Hashii HT Y. Arai. Contributed reagents/materials/analysis tools: Y. Abe Y. Arai N. Hirose. Wrote the paper: TE YM N. Hashii Y. Arai NK N. Hirose.