About the Authors

Tao Xie

tao.xie@pfizer.com (TX); mhidalgo@cnio.es (MH)

Affiliation Oncology Research, Pfizer Worldwide Research and Development, San Diego, California, United States of America

Monica Musteanu

Affiliation CNIO (Spanish National Cancer Research Centre), E-28029, Madrid, Madrid, Spain

Pedro P. Lopez-Casas

Affiliation CNIO (Spanish National Cancer Research Centre), E-28029, Madrid, Madrid, Spain

David J. Shields

Affiliation Oncology Research, Pfizer Worldwide Research and Development, San Diego, California, United States of America

Peter Olson

Affiliation Oncology Research, Pfizer Worldwide Research and Development, San Diego, California, United States of America

Paul A. Rejto

Affiliation Oncology Research, Pfizer Worldwide Research and Development, San Diego, California, United States of America

Manuel Hidalgo

tao.xie@pfizer.com (TX); mhidalgo@cnio.es (MH)

Affiliation CNIO (Spanish National Cancer Research Centre), E-28029, Madrid, Madrid, Spain

Competing Interests

The authors have the following interests: The study was funded by Pfizer Inc. Tao Xie, David J. Shields, Peter Olson and Paul A. Rejto are employees of Pfizer. There are no patents, products in development or marketed products to declare. This did not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TX DJS PO PAR MH. Performed the experiments: MM PPL. Analyzed the data: TX DJS PO. Contributed reagents/materials/analysis tools: TX MM PPL DJS PO. Wrote the paper: TX MM PPL DJS PO PAR MH.