About the Authors

Alvaro Alonso

alonso@umn.edu

Affiliation Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America

Bing Yu

Affiliation Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

Waqas T. Qureshi

Affiliation Division of Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

Morgan E. Grams

Affiliations Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

Elizabeth Selvin

Affiliations Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, United States of America

Elsayed Z. Soliman

Affiliations Epidemiological Cardiology Research Center (EPICARE), Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America, Department of Medicine-Cardiology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Laura R. Loehr

Affiliation Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America

Lin Y. Chen

Affiliation Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America

Sunil K. Agarwal

Affiliation Mount Sinai Heart Hospital, New York, New York, United States of America

Danny Alexander

Affiliation Metabolon, Inc., Durham, North Carolina, United States of America

Eric Boerwinkle

Affiliations Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, United States of America, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

Competing Interests

Danny Alexander is an employee of Metabolon, Inc. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AA BY WTQ MEG ES EZS LRL LYC SKA DA EB. Performed the experiments: AA BY DA EB. Analyzed the data: AA BY. Contributed reagents/materials/analysis tools: ES DA EB. Wrote the paper: AA BY WTQ MEG ES EZS LRL LYC SKA DA EB. Performed metabolites assessment: DA. Wrote initial draft of the manuscript: AA. Obtained funding: EB AA ES.