About the Authors

Xingsheng Hu

Contributed equally to this work with: Xingsheng Hu, Li Zhang

Affiliation Department of Medical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Beijing, China

Li Zhang

Contributed equally to this work with: Xingsheng Hu, Li Zhang

Affiliation Sun Yat-Sen University Cancer Center, Guangzhou, China

Yuankai Shi

Affiliation Department of Medical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Beijing, China

Caicun Zhou

Affiliation Shanghai Pulmonary Hospital, Tongji University, Shanghai, China

Xiaoqing Liu

Affiliation Department of Pulmonary Oncology, 307 Hospital of the Academy of Military Medical Sciences, Cancer Center, Beijing, China

Dong Wang

Affiliation Third Affiliated Hospital, The Third Military Medical University of People‘s Liberation Army, Chongqing, China

Yong Song

Affiliation Nanjing Military General Hospital, Nanjing, China

Qiang Li

Affiliation Changhai Hospital, The Second Military Medical University, Shanghai, China

Jifeng Feng

Affiliation Jiangsu Province Cancer Hospital, Nanjing, China

Shukui Qin

Affiliation Nanjing Bayi Hospital of People’s Liberation Army, Nanjing, China

Nong Xv

Affiliation The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou, China

Jianying Zhou

Affiliation The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou, China

Li Zhang

Affiliation Peking Union Medical College Hospital, Beijing, China

Chunhong Hu

Affiliation The Second Xiangya Hospital, Changsha, China

Shucai Zhang

Affiliation Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China

Rongcheng Luo

Affiliation Nanfang Hospital, Southern Medical University, Guangzhou, China

Jie Wang

Affiliation Beijing Cancer Hospital, Beijing, China

Fenlai Tan

Affiliation Betta Pharmaceuticals Co, Ltd, Hangzhou, China

Yinxiang Wang

Affiliation Betta Pharmaceuticals Co, Ltd, Hangzhou, China

Lieming Ding

Affiliation Betta Pharmaceuticals Co, Ltd, Hangzhou, China

Yan Sun

suny@csco.org.cn

Affiliation Department of Medical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Beijing, China

Competing Interests

The authors of this manuscript have the following competing interests: Fenlai Tan, Yinxiang Wang, and Lieming Ding are salaried employees of Betta Pharmaceuticals Co, Ltd. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials. All other authors had no competing interests.

Author Contributions

Conceived and designed the experiments: XSH LZ (2nd author) YKS CCZ XQL DW YongS QL JFF SKQ NX JYZ LZ (13th author) CHH SCZ RCL JW FLT YXW LMD YanS. Performed the experiments: XSH LZ (2nd author) YKS CCZ XQL DW YongS QL JFF SKQ NX JYZ LZ (13th author)CHH SCZ RCL JW YanS. Analyzed the data: XSH LZ (2nd author)YKS FLT YXW LMD YanS. Contributed reagents/materials/analysis tools: XSH LZ (2nd author) YKS FLT YXW LMD YanS. Wrote the paper: XSH LZ (2nd author) YKS CCZ XQL DW YongS QL JFF SKQ NX JYZ LZ (13th author) CHH SCZ RCL JW FLT YXW LMD YanS.