About the Authors

Vijayasree V. Giridharan

Affiliation J.K.K. Nattraja College of Pharmacy, Komarapalayam, Tamil Nadu, India

Rajarajan A. Thandavarayan

Contributed equally to this work with: Rajarajan A. Thandavarayan, Tetsuya Konishi

atrajarajan@gmail.com (RAT); konishi@nupals.ac.jp (TK)

Affiliation Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, Texas, United States of America

Somasundaram Arumugam

Affiliation Department of Clinical Pharmacology, Niigata University of Pharmacy & Applied Life Sciences (NUPALS), Niigata City, Japan

Makoto Mizuno

Affiliation Division of Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan

Hiroyuki Nawa

Affiliation Division of Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan

Kenji Suzuki

Affiliation Department of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

Kam M. Ko

Affiliation Section of Biochemistry and Cell biology, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China

Prasanna Krishnamurthy

Affiliation Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, Texas, United States of America

Kenichi Watanabe

Affiliation Department of Clinical Pharmacology, Niigata University of Pharmacy & Applied Life Sciences (NUPALS), Niigata City, Japan

Tetsuya Konishi

Contributed equally to this work with: Rajarajan A. Thandavarayan, Tetsuya Konishi

atrajarajan@gmail.com (RAT); konishi@nupals.ac.jp (TK)

Affiliation Basic studies on second generation functional foods, NUPALS, NUPALS Liaison R/D promotion division, Niigata, Japan, Changchun University of Chinese Medicine, Changchun, RP China

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VVG RAT TK. Performed the experiments: VVG RAT SA MM. Analyzed the data: VVG RAT SA TK. Contributed reagents/materials/analysis tools: RAT HN KS KMK KW PK TK. Wrote the paper: VVG RAT SA TK.