About the Authors

Akihiko Urayama

Affiliation Department of Neurology, University of Texas Medical School at Houston, Houston, TX, United States of America

Shinya Dohgu

Affiliation Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka, Japan

Sandra M. Robinson

Affiliation Division of Geriatric Medicine, Department of Internal Medicine, Saint Louis University, St. Louis, MO, United States of America

William S. Sly

Affiliation Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO, United States of America

Jeffery H. Grubb

Affiliation Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO, United States of America

William A Banks

wabanks1@uw.edu

Affiliations Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States of America, Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA, United States of America

Competing Interests

The authors have the following interests: This study was funded in part by an undesignated grant from Shire. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AU SD WSS WAB. Performed the experiments: AU SMR JHG. Analyzed the data: AU SD WAB SMR. Contributed reagents/materials/analysis tools: WSS JHG. Wrote the paper: AU SD WSS WAB SMR JHG.