About the Authors

Kimberley E. Wever

kim.wever@radboudumc.nl

Affiliation Systematic Review Centre for Laboratory animal Experimentation (SYRCLE), Radboud University Medical Center, Nijmegen, The Netherlands

Carlijn R. Hooijmans

Affiliation Systematic Review Centre for Laboratory animal Experimentation (SYRCLE), Radboud University Medical Center, Nijmegen, The Netherlands

Niels P. Riksen

Affiliation Department of Internal Medicine and Dept. of Pharmacology-Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands

Thomas B. Sterenborg

Affiliation Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands

Emily S. Sena

Affiliation Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom

Merel Ritskes-Hoitinga

Affiliation Systematic Review Centre for Laboratory animal Experimentation (SYRCLE), Radboud University Medical Center, Nijmegen, The Netherlands

Michiel C. Warlé

Affiliation Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands

Competing Interests

The authors have declared that no competing interests exist. NPR served on a Scientific Advisory Board of Astra Zeneca, which is unrelated to the current paper. KEW performed part of this work on a travelling fellowship from the Company of Biologists. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KW CH MR MW. Performed the experiments: KW CH TS MW. Analyzed the data: KW ES. Contributed reagents/materials/analysis tools: KW CH ES. Wrote the paper: KW CH NR ES MW MR.