About the Authors

Jessie J. Hsu

Affiliations Massachusetts General Hospital Biostatistics Center, Boston, MA, United States of America, Biostatistics Department, Harvard School of Public Health, Boston, MA, United States of America, Genentech, Inc., South San Francisco, CA, United States of America

Dianne M. Finkelstein

dfinkelstein@mgh.harvard.edu

Affiliations Massachusetts General Hospital Biostatistics Center, Boston, MA, United States of America, Biostatistics Department, Harvard School of Public Health, Boston, MA, United States of America

David A. Schoenfeld

Affiliations Massachusetts General Hospital Biostatistics Center, Boston, MA, United States of America, Biostatistics Department, Harvard School of Public Health, Boston, MA, United States of America

Competing Interests

The authors note that Dr. Jessie Hsu is now an employee of Genentech. This does not alter the authors’ adherence to PLOS policies on sharing data and materials. The other two authors have no conflicts to declare and this paper is not under review at any other journal.

Author Contributions

Conceived and designed the experiments: JH DS DF. Performed the experiments: JH. Analyzed the data: JH. Contributed reagents/materials/analysis tools: JH. Wrote the paper: JH DS DF.