About the Authors

Hongzhen Luo

Affiliation The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China

Laibing Ge

Affiliation China Shijiazhuang Pharmaceutical Group Co., Ltd., Shijiazhuang, Hebei, China

Jingshu Zhang

Affiliation China Shijiazhuang Pharmaceutical Group Co., Ltd., Shijiazhuang, Hebei, China

Yanli Zhao

Affiliation Hebei Changshan Biochemical Pharmaceutical Co., Ltd., Shijiazhuang, Hebei, China

Jian Ding

Affiliation The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China

Zhigang Li

Affiliation The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China

Zhenni He

Affiliation The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China

Rui Chen

Affiliation The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China

Zhongping Shi

zpshi@jiangnan.edu.cn

Affiliation The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China

Competing Interests

The authors can confirm that the co-authors L. Ge and J. Zhang are employed by CSPC, and Y. Zhao is employed by CSBIO. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HL ZS ZL JD. Performed the experiments: HL LG JZ YZ JD ZL ZH RC ZS. Analyzed the data: HL ZL ZS. Contributed reagents/materials/analysis tools: HL LG JZ YZ JD ZL ZH RC ZS. Wrote the paper: HL ZS.