About the Authors

Paolo Denti

Contributed equally to this work with: Paolo Denti, Kidola Jeremiah

Affiliation Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

Kidola Jeremiah

Contributed equally to this work with: Paolo Denti, Kidola Jeremiah

jkidola@gmail.com

Affiliations Department of Infectious Diseases, Odense University Hospital, Odense, Denmark, National Institute for Medical Research, Mwanza Medical Research Centre, Mwanza, Tanzania

Emmanuel Chigutsa

Current Address: Eli Lilly and Company, Indianapolis, Indiana, United State of America

Affiliation Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

Daniel Faurholt-Jepsen

Affiliation Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark

George PrayGod

Affiliation National Institute for Medical Research, Mwanza Medical Research Centre, Mwanza, Tanzania

Nyagosya Range

Affiliation National Institute for Medical Research, Muhimbili Research Centre, Dar Es Salaam, Tanzania

Sandra Castel

Affiliation Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

Lubbe Wiesner

Affiliation Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

Christian Munch Hagen

Affiliation Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark

Michael Christiansen

Affiliation Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark

John Changalucha

Affiliation National Institute for Medical Research, Mwanza Medical Research Centre, Mwanza, Tanzania

Helen McIlleron

Affiliation Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

Henrik Friis

Affiliation Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark

Aase Bengaard Andersen

Affiliations Department of Infectious Diseases, Odense University Hospital, Odense, Denmark, Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark

Competing Interests

Dr. Emmanuel Chigutsa was a PhD student at the University of Cape Town while he first contributed to this work. After he graduated in 2013, Dr. Chigutsa moved to Eli Lilly and Company as post-doctoral fellow. However, Eli Lilly and Company was not involved in this work, since the Danish Ministry of Foreign Affairs (DANIDA, DFC file no. 09-026RH) through the Denmark’s International Development Cooperation entirely supported this study. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ABA NR HF HM JC. Performed the experiments: KJ GP LW SC DFJ EC PD CMH MC. Analyzed the data: KJ PD EC DFJ. Wrote the paper: KJ PD. Contributed to interpretation of the results and comments on drafts and approved the final version: ABA NR HF HM KJ GP LW SC DFJ EC JC PD MC CMH.