About the Authors

Richard B. Lanman

Contributed equally to this work with: Richard B. Lanman, Stefanie A. Mortimer

atalasaz@guardanthealth.com

Affiliation Department of Medical Affairs, Guardant Health, Inc., Redwood City, California, United States of America

Stefanie A. Mortimer

Contributed equally to this work with: Richard B. Lanman, Stefanie A. Mortimer

Affiliation Department of Research and Bioinformatics, Guardant Health, Inc., Redwood City, California, United States of America

Oliver A. Zill

Affiliation Department of Research and Bioinformatics, Guardant Health, Inc., Redwood City, California, United States of America

Dragan Sebisanovic

Affiliation Department of Research and Bioinformatics, Guardant Health, Inc., Redwood City, California, United States of America

Rene Lopez

Affiliation Department of Research and Bioinformatics, Guardant Health, Inc., Redwood City, California, United States of America

Sibel Blau

Affiliation Rainier Hematology Oncology, Northwest Medical Specialties, Puyallup, Washington, United States of America

Eric A. Collisson

Affiliation Department of Medicine, University of California San Francisco School of Medicine, San Francisco, California, United States of America

Stephen G. Divers

Affiliation Genesis Cancer Center, Hot Springs, Arkansas, United States of America

Dave S. B. Hoon

Affiliation Department of Molecular Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California, United States of America

E. Scott Kopetz

Affiliation Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

Jeeyun Lee

Affiliation Department of Medicine, Division of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Petros G. Nikolinakos

Affiliation Department of Hematology and Medical Oncology, University Cancer and Blood Center, Athens, Georgia, United States of America

Arthur M. Baca

Affiliation Department of Medical Affairs, Guardant Health, Inc., Redwood City, California, United States of America

Bahram G. Kermani

Affiliation Department of Research and Bioinformatics, Guardant Health, Inc., Redwood City, California, United States of America

Helmy Eltoukhy

Affiliation Administration, Guardant Health, Inc., Redwood City, California, United States of America

AmirAli Talasaz

atalasaz@guardanthealth.com

Affiliations Department of Research and Bioinformatics, Guardant Health, Inc., Redwood City, California, United States of America, Administration, Guardant Health, Inc., Redwood City, California, United States of America

Competing Interests

The authors have the following interests. Richard B. Lanman, Stefanie A. Mortimer, Oliver A. Zill, Dragan Sebisanovic, Rene Lopez, Bahram G. Kermani, Helmy Eltoukhy and AmirAli Talasaz are/were employed by Guardant Health, Inc., the funder of this study. All authors with a Guardant Health, Inc. affiliation are current or former employees of and stockholders in Guardant Health Inc. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: SAM AT. Performed the experiments: SAM DS. Analyzed the data: RBL SAM OAZ EAC DSBH ESK JL PN AMB BGK HE AT. Contributed reagents/materials/analysis tools: OAZ EAC BGK HE AT RL. Wrote the paper: RBL SAM OAZ DS SB EAC SGD DSBH ESK JL PN AMB BGK HE AT. Contributed samples: SB EAC SGD DSBH ESK JL PN.