About the Authors

Aiko Ishiki

Affiliation Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai city, Miyagi prefecture, Japan

Nobuyuki Okamura

nookamura@med.tohoku.ac.jp

Affiliations Department of Pharmacology, Tohoku University School of Medicine, Sendai city, Miyagi prefecture, Japan, Division of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai city, Miyagi prefecture, Japan

Katsutoshi Furukawa

Affiliation Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai city, Miyagi prefecture, Japan

Shozo Furumoto

Affiliation Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai city, Miyagi prefecture, Japan

Ryuichi Harada

Affiliation Division of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai city, Miyagi prefecture, Japan

Naoki Tomita

Affiliation Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai city, Miyagi prefecture, Japan

Kotaro Hiraoka

Affiliation Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai city, Miyagi prefecture, Japan

Shoichi Watanuki

Affiliation Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai city, Miyagi prefecture, Japan

Yoichi Ishikawa

Affiliation Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai city, Miyagi prefecture, Japan

Tetsuro Tago

Affiliation Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai city, Miyagi prefecture, Japan

Yoshihito Funaki

Affiliation Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai city, Miyagi prefecture, Japan

Ren Iwata

Affiliation Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai city, Miyagi prefecture, Japan

Manabu Tashiro

Affiliation Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai city, Miyagi prefecture, Japan

Kazuhiko Yanai

Affiliation Department of Pharmacology, Tohoku University School of Medicine, Sendai city, Miyagi prefecture, Japan

Yukitsuka Kudo

Affiliations Division of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai city, Miyagi prefecture, Japan, Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai city, Miyagi prefecture, Japan

Hiroyuki Arai

Affiliation Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai city, Miyagi prefecture, Japan

Competing Interests

The authors have read the journal's policy and the authors of this manuscript have the following competing interests: YK, NO, and SF received research grants from GE Healthcare. YK also received research grants from Sumitomo Electric Industries. YK and NO own stock in Clino Ltd. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: NO KF KY YK HA. Performed the experiments: AI NO KF SF RH NT KH SW YI TT YF RI MT. Analyzed the data: AI NO SW. Contributed reagents/materials/analysis tools: SF RI YK. Wrote the paper: AI NO KF.