About the Authors

Sophia K. Smith

sophia.smith@duke.edu

Affiliation School of Nursing, Duke University, Durham, NC, United States of America

Wendy Selig

Affiliation WS Collaborative, McLean, VA, United States of America

Matthew Harker

Affiliation Clinical Trials Transformation Initiative, Duke Clinical Research Institute, Durham, NC, United States of America

Jamie N. Roberts

Affiliation Clinical Trials Transformation Initiative, Duke Clinical Research Institute, Durham, NC, United States of America

Sharon Hesterlee

Affiliation Parent Project Muscular Dystrophy, Hackensack, NJ, United States of America

David Leventhal

Affiliation Pfizer Worldwide Research and Development, Groton, CT, United States of America

Richard Klein

Affiliation U.S. Food and Drug Administration, Silver Spring, MD, United States of America

Bray Patrick-Lake

Affiliation Clinical Trials Transformation Initiative, Duke Clinical Research Institute, Durham, NC, United States of America

Amy P. Abernethy

Affiliation Flatiron Health, New York, NY, United States of America

Competing Interests

Financial activities outside the submitted work include (1) Until 3/31/2015, WS was president and CEO of Melanoma Research Alliance and is presently founder and CEO of WS Collaborative LLC; (2) SH serves on the Board of Directors of the Health Research Alliance, a professional organization representing over 60 nonprofit patient organizations and health funding foundations, and has received funding to attend conferences conducted by Parent Project Muscular Dystrophy (PPMD) from PTC Therapeutics, Sarepta Therapeutics, Pfizer, Lilly, Shire, Prosensa, Catabasis, Tivorsan, Summit PLC, and Halo Therapeutics; (3) DL is the director of clinical innovation at Pfizer Worldwide Research and Development, (4) APA is chief medical officer and senior vice president of oncology at Flatiron Health Inc. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials. The other authors have no disclosures related to financial or nonfinancial activities.

Author Contributions

Conceived and designed the experiments: SS WS MH JR SH DL RK BP AA. Analyzed the data: SS WS MH JR SH DL RK BP AA. Wrote the paper: SS WS MH JR SH DL RK BP AA.