About the Authors
- Gertjan Kramer
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* E-mail: gertjan.kramer@embl.de
Current address: Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
Affiliation Department of Medical Biochemistry, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
- Yvonne Woolerton
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Affiliation Centre for Proteome Research, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
- Jan P. van Straalen
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Affiliation Department of Clinical Chemistry, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
- Johannes P. C. Vissers
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Affiliation Waters Corporation, MS Technologies Centre, Manchester, United Kingdom
- Nick Dekker
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Affiliation Department of Medical Biochemistry, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
- James I. Langridge
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Affiliation Waters Corporation, MS Technologies Centre, Manchester, United Kingdom
- Robert J. Beynon
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Affiliation Centre for Proteome Research, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
- Dave Speijer
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Affiliation Department of Medical Biochemistry, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
- Auguste Sturk
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Affiliation Department of Clinical Chemistry, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
- Johannes M. F. G. Aerts
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Affiliation Department of Medical Biochemistry, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
Competing Interests
Authors JPCV and JIL are employed by Waters Corporation. The methods described in the manuscript make use of the following Waters Corporation marketed products: a nanoAcquity system, a Synapt G2 MS mass spectrometer, ProteinLynx GlobalSERVER (PLGS) v2.5, Mass Prep Quantitation standard, and RapiGest SF. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: GK JMFGA AS. Performed the experiments: GK YW JPvS. Analyzed the data: GK ND JPvS JPCV YW DS. Contributed reagents/materials/analysis tools: YW RJB JPvS AS JIL JPCV. Wrote the paper: GK DS ND YW RJB JPvS AS JMFGA JIL JPCV. Provided technical support during the mass-spectrometry measurements and advised on data analysis, but did not have any undue influence in the study design, data collection and analysis, decision to publish, or preparation of the manuscript: JPCV JIL.