About the Authors

Jing Wang

Contributed equally to this work with: Jing Wang, Zaoli Jiang

Affiliations Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Oncology and Hematology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China

Zaoli Jiang

Contributed equally to this work with: Jing Wang, Zaoli Jiang

Affiliation Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States of America

Wing Lam

Affiliation Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States of America

Elizabeth A. Gullen

Affiliation Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States of America

Zhe Yu

Affiliation School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China

Ying Wei

Affiliation School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China

Lihui Wang

Affiliation School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China

Caroline Zeiss

Affiliation Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America

Amanda Beck

Affiliation Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America

Ee-Chun Cheng

Affiliation Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States of America

Chunfu Wu

Affiliation School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China

Yung-Chi Cheng

yccheng@yale.edu (YCC); zhangyxzsh@163.com (YZ)

Affiliation Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States of America

Yixuan Zhang

yccheng@yale.edu (YCC); zhangyxzsh@163.com (YZ)

Affiliation School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YCC YZ JW ZJ WL EAG. Performed the experiments: JW ZJ WL EAG ZY YW LW CZ AB ECC CW. Analyzed the data: JW ZJ WL EAG CZ AB ECC YCC. Contributed reagents/materials/analysis tools: YZ YCC JW EAG WL CZ ECC. Wrote the paper: JW YCC EAG CZ AB WL ZY YW LW CW. Revised the manuscript critically for important intellectual content: YCC WL YZ EAG ZJ CZ ECC.