Alterations in Hepatic FGF21, Co-Regulated Genes, and Upstream Metabolic Genes in Response to Nutrition, Ketosis and Inflammation in Peripartal Holstein Cows

Haji Akbar; Fernanda Batistel; James K. Drackley; Juan J. Loor

doi:10.1371/journal.pone.0139963

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Open Access

Peer-reviewed

Research Article

Alterations in Hepatic FGF21, Co-Regulated Genes, and Upstream Metabolic Genes in Response to Nutrition, Ketosis and Inflammation in Peripartal Holstein Cows

Haji Akbar,

Affiliation Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, Illinois, United States of America
⨯
Fernanda Batistel,

Affiliation Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, Illinois, United States of America
⨯
James K. Drackley,

Affiliation Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, Illinois, United States of America
⨯
Juan J. Loor

* E-mail: jloor@illinois.edu

Affiliation Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, Illinois, United States of America
⨯

Alterations in Hepatic FGF21, Co-Regulated Genes, and Upstream Metabolic Genes in Response to Nutrition, Ketosis and Inflammation in Peripartal Holstein Cows

Haji Akbar,
Fernanda Batistel,
James K. Drackley,
Juan J. Loor

Published: October 9, 2015
https://doi.org/10.1371/journal.pone.0139963

About the Authors

Haji Akbar

Affiliation Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, Illinois, United States of America

Fernanda Batistel

Affiliation Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, Illinois, United States of America

James K. Drackley

Affiliation Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, Illinois, United States of America

Juan J. Loor

* E-mail: jloor@illinois.edu

Affiliation Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, Illinois, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JJL JKD. Performed the experiments: HA. Analyzed the data: HA FB JJL. Contributed reagents/materials/analysis tools: JKD. Wrote the paper: HA FB JKD JJL.

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Diet
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Fibroblast growth factor
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Inflammation
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Gene expression
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Glucagon
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Oxidation
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Adipose tissue
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Rodents
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