About the Authors

Chaoying Hu

Affiliation Phase I Clinical Research Unit, Shanghai Xuhui Central Hospital, Shanghai, China

Debra Tompson

yliu@shxh-centerlab.com (YL); debra.j.tompson@gsk.com (DT)

Affiliation Clinical Pharmacology Modeling and Simulation, GSK Medicines Research Centre, Stevenage, United Kingdom

Mindy Magee

Affiliation Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America

Qian Chen

Affiliation Phase I Clinical Research Unit, Shanghai Xuhui Central Hospital, Shanghai, China

Yan Mei Liu

Affiliation Phase I Clinical Research Unit, Shanghai Xuhui Central Hospital, Shanghai, China

Wenjing Zhu

Affiliation China Medicine Development, GlaxoSmithKline (China) R&D Company Limited, Shanghai, China

Hongxin Zhao

Affiliation China Medicine Development, GlaxoSmithKline (China) R&D Company Limited, Shanghai, China

Annette S. Gross

Affiliation Ethnopharmacology, GlaxoSmithKline, Sydney, Australia

Yun Liu

yliu@shxh-centerlab.com (YL); debra.j.tompson@gsk.com (DT)

Affiliation Phase I Clinical Research Unit, Shanghai Xuhui Central Hospital, Shanghai, China

Competing Interests

DT, MM, WZ and AG are GlaxoSmithKline employees and own GSK stock. HZ is a GSK employee. CH, QC, YML and YL have no conflicts of interests to declare. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CH QC YML WZ HZ YL. Performed the experiments: CH QC YML YL. Analyzed the data: DT WZ HZ. Contributed reagents/materials/analysis tools: DT MM WZ HZ AG. Wrote the paper: DT MM WZ HZ AG. Principal author of the manuscript: DT. Critical review and approval the final version of manuscript: CH DT MM QC YML WZ HZ AG YL.