Attenuation of Inflammatory Mediators (TNF-α and Nitric Oxide) and Up-Regulation of IL-10 by Wild and Domesticated Basidiocarps of Amauroderma rugosum (Blume & T. Nees) Torrend in LPS-Stimulated RAW264.7 Cells

Pui-Mun Chan; Yee-Shin Tan; Kek-Heng Chua; Vikineswary Sabaratnam; Umah Rani Kuppusamy

doi:10.1371/journal.pone.0139593

Loading metrics

Open Access

Peer-reviewed

Research Article

Attenuation of Inflammatory Mediators (TNF-α and Nitric Oxide) and Up-Regulation of IL-10 by Wild and Domesticated Basidiocarps of Amauroderma rugosum (Blume & T. Nees) Torrend in LPS-Stimulated RAW264.7 Cells

Pui-Mun Chan ,

Contributed equally to this work with: Pui-Mun Chan, Yee-Shin Tan, Kek-Heng Chua, Vikineswary Sabaratnam, Umah Rani Kuppusamy

Affiliations Mushroom Research Centre, University of Malaya, 50603, Kuala Lumpur, Malaysia, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
⨯
Yee-Shin Tan ,

Contributed equally to this work with: Pui-Mun Chan, Yee-Shin Tan, Kek-Heng Chua, Vikineswary Sabaratnam, Umah Rani Kuppusamy

Affiliations Mushroom Research Centre, University of Malaya, 50603, Kuala Lumpur, Malaysia, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
⨯
Kek-Heng Chua ,

Contributed equally to this work with: Pui-Mun Chan, Yee-Shin Tan, Kek-Heng Chua, Vikineswary Sabaratnam, Umah Rani Kuppusamy

Affiliations Mushroom Research Centre, University of Malaya, 50603, Kuala Lumpur, Malaysia, Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
⨯
Vikineswary Sabaratnam ,

Contributed equally to this work with: Pui-Mun Chan, Yee-Shin Tan, Kek-Heng Chua, Vikineswary Sabaratnam, Umah Rani Kuppusamy

Affiliations Mushroom Research Centre, University of Malaya, 50603, Kuala Lumpur, Malaysia, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
⨯
Umah Rani Kuppusamy

Contributed equally to this work with: Pui-Mun Chan, Yee-Shin Tan, Kek-Heng Chua, Vikineswary Sabaratnam, Umah Rani Kuppusamy

* E-mail: umah@um.edu.my

Affiliations Mushroom Research Centre, University of Malaya, 50603, Kuala Lumpur, Malaysia, Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
⨯

Attenuation of Inflammatory Mediators (TNF-α and Nitric Oxide) and Up-Regulation of IL-10 by Wild and Domesticated Basidiocarps of Amauroderma rugosum (Blume & T. Nees) Torrend in LPS-Stimulated RAW264.7 Cells

Pui-Mun Chan,
Yee-Shin Tan,
Kek-Heng Chua,
Vikineswary Sabaratnam,
Umah Rani Kuppusamy

Published: October 1, 2015
https://doi.org/10.1371/journal.pone.0139593

About the Authors

Pui-Mun Chan

Contributed equally to this work with: Pui-Mun Chan, Yee-Shin Tan, Kek-Heng Chua, Vikineswary Sabaratnam, Umah Rani Kuppusamy

Affiliations Mushroom Research Centre, University of Malaya, 50603, Kuala Lumpur, Malaysia, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia

Yee-Shin Tan

Contributed equally to this work with: Pui-Mun Chan, Yee-Shin Tan, Kek-Heng Chua, Vikineswary Sabaratnam, Umah Rani Kuppusamy

Affiliations Mushroom Research Centre, University of Malaya, 50603, Kuala Lumpur, Malaysia, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia

Kek-Heng Chua

Contributed equally to this work with: Pui-Mun Chan, Yee-Shin Tan, Kek-Heng Chua, Vikineswary Sabaratnam, Umah Rani Kuppusamy

Affiliations Mushroom Research Centre, University of Malaya, 50603, Kuala Lumpur, Malaysia, Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia

Vikineswary Sabaratnam

Contributed equally to this work with: Pui-Mun Chan, Yee-Shin Tan, Kek-Heng Chua, Vikineswary Sabaratnam, Umah Rani Kuppusamy

Affiliations Mushroom Research Centre, University of Malaya, 50603, Kuala Lumpur, Malaysia, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia

Umah Rani Kuppusamy

Contributed equally to this work with: Pui-Mun Chan, Yee-Shin Tan, Kek-Heng Chua, Vikineswary Sabaratnam, Umah Rani Kuppusamy

* E-mail: umah@um.edu.my

Affiliations Mushroom Research Centre, University of Malaya, 50603, Kuala Lumpur, Malaysia, Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PMC YST KHC VS URK. Performed the experiments: PMC. Analyzed the data: PMC URK KHC. Contributed reagents/materials/analysis tools: URK VS YST. Wrote the paper: PMC URK VS.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Nitric oxide
Is the Subject Area "Nitric oxide" applicable to this article?

Thanks for your feedback.
Transcription factors
Is the Subject Area "Transcription factors" applicable to this article?

Thanks for your feedback.
Inflammatory diseases
Is the Subject Area "Inflammatory diseases" applicable to this article?

Thanks for your feedback.
Antioxidants
Is the Subject Area "Antioxidants" applicable to this article?

Thanks for your feedback.
Phenols
Is the Subject Area "Phenols" applicable to this article?

Thanks for your feedback.
Domestic animals
Is the Subject Area "Domestic animals" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.