About the Authors

Naoto Tanaka

Contributed equally to this work with: Naoto Tanaka, Emily V. Dutrow

Affiliation Department of Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, United States of America

Emily V. Dutrow

Contributed equally to this work with: Naoto Tanaka, Emily V. Dutrow

Affiliation Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Keiko Miyadera

Affiliation Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Lucie Delemotte

Affiliation Institute for Computational Molecular Science, Temple University, Philadelphia, Pennsylvania, United States of America

Christopher M. MacDermaid

Affiliation Institute for Computational Molecular Science, Temple University, Philadelphia, Pennsylvania, United States of America

Shelby L. Reinstein

Affiliation Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

William R. Crumley

Affiliation Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Christopher J. Dixon

Affiliation Veterinary Vision, Penrith, Cumbria, CA11 9FJ, United Kingdom

Margret L. Casal

Affiliation Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Michael L. Klein

Affiliation Institute for Computational Molecular Science, Temple University, Philadelphia, Pennsylvania, United States of America

Gustavo D. Aguirre

Affiliation Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Jacqueline C. Tanaka

jtanaka@temple.edu (JCT); karinag@vet.upenn.edu (KEG)

Affiliation Department of Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, United States of America

Karina E. Guziewicz

jtanaka@temple.edu (JCT); karinag@vet.upenn.edu (KEG)

Affiliation Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Competing Interests

CJD is a co-owner of a private veterinary practice, Veterinary Vision (Penrith, UK). This affiliation did not have any role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. This does not alter the authors' adherence to all PLOS ONE polices on sharing data and materials. All remaining authors declare no conflicts of interest.

Author Contributions

Conceived and designed the experiments: KEG GDA EVD JCT NT. Performed the experiments: EVD KM SLR WRC MLC KEG GDA JCT CMM LD NT. Analyzed the data: KEG EVD KM CJD JCT CMM GDA LD NT. Contributed reagents/materials/analysis tools: GDA KEG EVD KM CJD MLC JCT CMM LD NT. Wrote the paper: EVD NT KEG JCT CMM LD GDA MLK.