About the Authors
- Seong-Ho Koh
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Contributed equally to this work with: Seong-Ho Koh, Anna C. Liang, Yoko Takahashi
Affiliations Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America, Department of Neurology, Hanyang University College of Medicine, Seoul, Korea
- Anna C. Liang
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Contributed equally to this work with: Seong-Ho Koh, Anna C. Liang, Yoko Takahashi
Affiliation Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
- Yoko Takahashi
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Contributed equally to this work with: Seong-Ho Koh, Anna C. Liang, Yoko Takahashi
Affiliations Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America, Department of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
- Takakuni Maki
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Affiliation Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
- Akihiro Shindo
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Affiliation Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
- Noriko Osumi
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Affiliation Department of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
- Jing Zhao
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Affiliation Regenerative Medicine Discovery Performance Unit, GlaxoSmithKline, Cambridge, Massachusetts, United States of America
- Hong Lin
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Affiliation Regenerative Medicine Discovery Performance Unit, GlaxoSmithKline, Cambridge, Massachusetts, United States of America
- Julie C. Holder
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Affiliation Regenerative Medicine Discovery Performance Unit, GlaxoSmithKline, Cambridge, Massachusetts, United States of America
- Tsu Tshen Chuang
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Current Address: Plasticell Ltd., Stevenage Bioscience Catalyst, Stevenage, United Kingdom
Affiliation Regenerative Medicine Discovery Performance Unit, GlaxoSmithKline, Cambridge, Massachusetts, United States of America
- John D. McNeish
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Affiliation Regenerative Medicine Discovery Performance Unit, GlaxoSmithKline, Cambridge, Massachusetts, United States of America
- Ken Arai
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Affiliation Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
- Eng H. Lo
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* E-mail: Lo@helix.mgh.harvard.edu
Affiliation Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
Competing Interests
Several authors (JZ, HL, JCH, TTC, and JDM) were employed and paid by Glaxo-Smith-Kline. But this does not alter the authors’ adherence to PLOS ONE policies on data sharing materials. Isx-9 is not a Glaxo-Smith-Kline compound, and belongs to the public domain.
Author Contributions
Conceived and designed the experiments: SHK NO JZ HL JCH TTC JDM KA EHL. Performed the experiments: SHK ACL YT TM AS JZ HL. Analyzed the data: SHK ACL YT HL JCH TTC KA EHL. Contributed reagents/materials/analysis tools: JZ HL JCH TTC JDM. Wrote the paper: SHK HL JCH TTC JDM KA EHL.