About the Authors

Daniela Herrera Moro Chao

Affiliations Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands, Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands

Wouter W. Kallemeijn

Affiliations Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands, Department of Biochemistry, Leiden Insitute of Chemistry, Leiden, The Netherlands

Andre R. A. Marques

Affiliation Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands

Marie Orre

Affiliation Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

Roelof Ottenhoff

Affiliation Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands

Cindy van Roomen

Affiliation Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands

Ewout Foppen

Affiliation Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands

Maria C. Renner

Affiliation Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

Martina Moeton

Affiliation Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

Marco van Eijk

Affiliation Department of Biochemistry, Leiden Insitute of Chemistry, Leiden, The Netherlands

Rolf G. Boot

Affiliation Department of Biochemistry, Leiden Insitute of Chemistry, Leiden, The Netherlands

Willem Kamphuis

Affiliation Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

Elly M. Hol

Affiliations Netherlands Institute for Neuroscience, Amsterdam, The Netherlands, Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands, Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands

Jan Aten

Affiliation Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands

Hermen S. Overkleeft

Affiliation Department of Bio-organic Synthesis, Leiden institute of Chemistry, Leiden, The Netherlands

Andries Kalsbeek

Affiliations Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

Johannes M. F. G. Aerts

j.m.f.g.aerts@lic.leidenuniv.nl

Affiliation Department of Biochemistry, Leiden Insitute of Chemistry, Leiden, The Netherlands

Competing Interests

JA and HO are inventors on a patent application on cyclophellitol-epoxide ABP. Name of the patent: Activity Based Probes (ABPS0 interacting with glycosidases). Inventors: J.M.F.G. Aerts & H.S. Overkleeft. US Patent no: US 9,056,847 B2 (date of patent Jun. 16, 2015). There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DH W. Kallemeijn J. Aerts. Performed the experiments: DH W. Kallemeijn AM MO RO CR EF MR J. Aten. Analyzed the data: DH W. Kallemeijn AM MO MM J. Aten. Contributed reagents/materials/analysis tools: W. Kamphuis EH HO. Wrote the paper: DH W. Kallemeijn ME RB AK J. Aerts.