Optical Isomers of Atorvastatin, Rosuvastatin and Fluvastatin Enantiospecifically Activate Pregnane X Receptor PXR and Induce CYP2A6, CYP2B6 and CYP3A4 in Human Hepatocytes

Martina Korhonova; Aneta Doricakova; Zdenek Dvorak

doi:10.1371/journal.pone.0137720

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Peer-reviewed

Research Article

Optical Isomers of Atorvastatin, Rosuvastatin and Fluvastatin Enantiospecifically Activate Pregnane X Receptor PXR and Induce CYP2A6, CYP2B6 and CYP3A4 in Human Hepatocytes

Martina Korhonova,

Affiliation Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Slechtitelu 27, 783 71, Olomouc, Czech Republic
⨯
Aneta Doricakova,

Affiliation Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Slechtitelu 27, 783 71, Olomouc, Czech Republic
⨯
Zdenek Dvorak

* E-mail: moulin@email.cz

Affiliation Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Slechtitelu 27, 783 71, Olomouc, Czech Republic
⨯

Optical Isomers of Atorvastatin, Rosuvastatin and Fluvastatin Enantiospecifically Activate Pregnane X Receptor PXR and Induce CYP2A6, CYP2B6 and CYP3A4 in Human Hepatocytes

Martina Korhonova,
Aneta Doricakova,
Zdenek Dvorak

Published: September 14, 2015
https://doi.org/10.1371/journal.pone.0137720

About the Authors

Martina Korhonova

Affiliation Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Slechtitelu 27, 783 71, Olomouc, Czech Republic

Aneta Doricakova

Affiliation Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Slechtitelu 27, 783 71, Olomouc, Czech Republic

Zdenek Dvorak

* E-mail: moulin@email.cz

Affiliation Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Slechtitelu 27, 783 71, Olomouc, Czech Republic

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZD. Performed the experiments: MK AD. Analyzed the data: MK AD ZD. Contributed reagents/materials/analysis tools: ZD. Wrote the paper: MK ZD.

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Statins
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Enantiomers
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Hepatocytes
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Isomers
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Luciferase
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Transfection
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Drug-drug interactions
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Transcriptional control
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