The Molecular Mechanism of Amyloid β42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins

Magdalena Cieślik; Grzegorz A. Czapski; Joanna B. Strosznajder

doi:10.1371/journal.pone.0137193

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Open Access

Peer-reviewed

Research Article

The Molecular Mechanism of Amyloid β42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins

Magdalena Cieślik ,

Contributed equally to this work with: Magdalena Cieślik, Grzegorz A. Czapski

Affiliation Department of Cellular Signalling, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland
⨯
Grzegorz A. Czapski ,

Contributed equally to this work with: Magdalena Cieślik, Grzegorz A. Czapski

Affiliation Department of Cellular Signalling, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland
⨯
Joanna B. Strosznajder

* E-mail: jstrosznajder@imdik.pan.pl

Affiliation Department of Cellular Signalling, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland
⨯

The Molecular Mechanism of Amyloid β42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins

Magdalena Cieślik,
Grzegorz A. Czapski,
Joanna B. Strosznajder

Published: September 3, 2015
https://doi.org/10.1371/journal.pone.0137193

About the Authors

Magdalena Cieślik

Contributed equally to this work with: Magdalena Cieślik, Grzegorz A. Czapski

Affiliation Department of Cellular Signalling, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland

Grzegorz A. Czapski

Contributed equally to this work with: Magdalena Cieślik, Grzegorz A. Czapski

Affiliation Department of Cellular Signalling, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland

Joanna B. Strosznajder

* E-mail: jstrosznajder@imdik.pan.pl

Affiliation Department of Cellular Signalling, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MC GAC JBS. Performed the experiments: MC GAC. Analyzed the data: MC GAC JBS. Contributed reagents/materials/analysis tools: JBS. Wrote the paper: MC GAC JBS.

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Mitochondria
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Gene expression
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Alzheimer's disease
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Toxicity
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Cell death
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Phosphorylation
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Apoptosis
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Sphingolipids
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