About the Authors

Eva M. Marco

Current address: Dept. Physiology (Animal Physiology II), Faculty of Biological Sciences, Universidad Complutense de Madrid (UCM), Madrid, Spain

Affiliation Section of Behavioural Neuroscience, Dept. Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy

Cinzia Rapino

Affiliation Dept. Biomedical Sciences, Università degli Studi di Teramo, Teramo, Italy

Antonio Caprioli

Affiliation Sigma-Tau R&D, Pomezia, Italy

Franco Borsini

Affiliation Sigma-Tau R&D, Pomezia, Italy

Giovanni Laviola

giovanni.laviola@iss.it (GL); m.maccarrone@unicampus.it (MM)

Affiliation Section of Behavioural Neuroscience, Dept. Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy

Mauro Maccarrone

giovanni.laviola@iss.it (GL); m.maccarrone@unicampus.it (MM)

Affiliations School of Medicine, Campus Bio-Medico University of Rome, Rome, Italy, Centro Europeo di Ricerca sul Cervello (CERC)/IRCCS Fondazione Santa Lucia, Rome, Italy

Competing Interests

The authors declare a commercial affiliation with the Drug Company ALFASIGMA (current name for formerly Sigma-Tau). This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: EMM AC FB GL MM. Performed the experiments: EMM CR AC. Analyzed the data: EMM CR AC. Contributed reagents/materials/analysis tools: EMM CR AC FB GL MM. Wrote the paper: EMM GL MM.