A Single Dynamic Metabolic Model Can Describe mAb Producing CHO Cell Batch and Fed-Batch Cultures on Different Culture Media

Julien Robitaille; Jingkui Chen; Mario Jolicoeur

doi:10.1371/journal.pone.0136815

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Open Access

Peer-reviewed

Research Article

A Single Dynamic Metabolic Model Can Describe mAb Producing CHO Cell Batch and Fed-Batch Cultures on Different Culture Media

Julien Robitaille,

Affiliation Research Laboratory in Applied Metabolic Engineering, Department of Chemical Engineering, École Polytechnique de Montréal, C.P. 6079, Centre-ville Station, Montreal (Quebec), Canada
⨯
Jingkui Chen,

Affiliation Research Laboratory in Applied Metabolic Engineering, Department of Chemical Engineering, École Polytechnique de Montréal, C.P. 6079, Centre-ville Station, Montreal (Quebec), Canada
⨯
Mario Jolicoeur

* E-mail: mario.jolicoeur@polymtl.ca

Affiliation Research Laboratory in Applied Metabolic Engineering, Department of Chemical Engineering, École Polytechnique de Montréal, C.P. 6079, Centre-ville Station, Montreal (Quebec), Canada
⨯

A Single Dynamic Metabolic Model Can Describe mAb Producing CHO Cell Batch and Fed-Batch Cultures on Different Culture Media

Julien Robitaille,
Jingkui Chen,
Mario Jolicoeur

Published: September 2, 2015
https://doi.org/10.1371/journal.pone.0136815

About the Authors

Julien Robitaille

Affiliation Research Laboratory in Applied Metabolic Engineering, Department of Chemical Engineering, École Polytechnique de Montréal, C.P. 6079, Centre-ville Station, Montreal (Quebec), Canada

Jingkui Chen

Affiliation Research Laboratory in Applied Metabolic Engineering, Department of Chemical Engineering, École Polytechnique de Montréal, C.P. 6079, Centre-ville Station, Montreal (Quebec), Canada

Mario Jolicoeur

* E-mail: mario.jolicoeur@polymtl.ca

Affiliation Research Laboratory in Applied Metabolic Engineering, Department of Chemical Engineering, École Polytechnique de Montréal, C.P. 6079, Centre-ville Station, Montreal (Quebec), Canada

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JR MJ. Performed the experiments: JR. Analyzed the data: JR MJ. Contributed reagents/materials/analysis tools: JC JR. Wrote the paper: JR MJ.

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Cell metabolism
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Glutamine
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Batch culture
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CHO cells
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Ammonia
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Citric acid cycle
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Glycolysis
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Culture media
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