Regulation of hedgehog Ligand Expression by the N-End Rule Ubiquitin-Protein Ligase Hyperplastic Discs and the Drosophila GSK3β Homologue, Shaggy

Sophie Moncrieff; Matthieu Moncan; Flavia Scialpi; Mark Ditzel

doi:10.1371/journal.pone.0136760

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Peer-reviewed

Research Article

Regulation of hedgehog Ligand Expression by the N-End Rule Ubiquitin-Protein Ligase Hyperplastic Discs and the Drosophila GSK3β Homologue, Shaggy

Sophie Moncrieff,

Affiliation MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh CRUK Cancer Research Centre, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XR, United Kingdom
⨯
Matthieu Moncan,

Affiliation MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh CRUK Cancer Research Centre, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XR, United Kingdom
⨯
Flavia Scialpi,

Affiliation MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh CRUK Cancer Research Centre, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XR, United Kingdom
⨯
Mark Ditzel

* E-mail: mark.ditzel@ed.ac.uk

Affiliation MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh CRUK Cancer Research Centre, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XR, United Kingdom
⨯

Regulation of hedgehog Ligand Expression by the N-End Rule Ubiquitin-Protein Ligase Hyperplastic Discs and the Drosophila GSK3β Homologue, Shaggy

Sophie Moncrieff,
Matthieu Moncan,
Flavia Scialpi,
Mark Ditzel

Published: September 3, 2015
https://doi.org/10.1371/journal.pone.0136760

About the Authors

Sophie Moncrieff

Affiliation MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh CRUK Cancer Research Centre, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XR, United Kingdom

Matthieu Moncan

Flavia Scialpi

Mark Ditzel

* E-mail: mark.ditzel@ed.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MD. Performed the experiments: SM MM FS MD. Analyzed the data: MD SM FS MM. Wrote the paper: MD.

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Cloning
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Hedgehog signaling
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Invertebrate genomics
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Drosophila melanogaster
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Eyes
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Fluorescence imaging
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Developmental signaling
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