DNA-Launched Alphavirus Replicons Encoding a Fusion of Mycobacterial Antigens Acr and Ag85B Are Immunogenic and Protective in a Murine Model of TB Infection

Neha Dalmia; William B. Klimstra; Carol Mason; Alistair J. Ramsay

doi:10.1371/journal.pone.0136635

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Open Access

Peer-reviewed

Research Article

DNA-Launched Alphavirus Replicons Encoding a Fusion of Mycobacterial Antigens Acr and Ag85B Are Immunogenic and Protective in a Murine Model of TB Infection

Neha Dalmia,

Affiliation Department of Microbiology, Immunology and Parasitology, LSU Health Sciences Center, New Orleans, Louisiana, United States of America
⨯
William B. Klimstra,

Affiliation Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Carol Mason,

Affiliation Department of Microbiology, Immunology and Parasitology, LSU Health Sciences Center, New Orleans, Louisiana, United States of America
⨯
Alistair J. Ramsay

* E-mail: aramsa@lsuhsc.edu

Affiliations Department of Microbiology, Immunology and Parasitology, LSU Health Sciences Center, New Orleans, Louisiana, United States of America, Department of Microbiology, Immunology and Parasitology, LSU Health Sciences Center, New Orleans, Louisiana, United States of America
⨯

DNA-Launched Alphavirus Replicons Encoding a Fusion of Mycobacterial Antigens Acr and Ag85B Are Immunogenic and Protective in a Murine Model of TB Infection

Neha Dalmia,
William B. Klimstra,
Carol Mason,
Alistair J. Ramsay

Published: August 28, 2015
https://doi.org/10.1371/journal.pone.0136635

About the Authors

Neha Dalmia

Affiliation Department of Microbiology, Immunology and Parasitology, LSU Health Sciences Center, New Orleans, Louisiana, United States of America

William B. Klimstra

Affiliation Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Carol Mason

Affiliation Department of Microbiology, Immunology and Parasitology, LSU Health Sciences Center, New Orleans, Louisiana, United States of America

Alistair J. Ramsay

* E-mail: aramsa@lsuhsc.edu

Affiliations Department of Microbiology, Immunology and Parasitology, LSU Health Sciences Center, New Orleans, Louisiana, United States of America, Department of Microbiology, Immunology and Parasitology, LSU Health Sciences Center, New Orleans, Louisiana, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ND WBK CM AJR. Performed the experiments: ND WBK AJR. Analyzed the data: ND AJR. Wrote the paper: ND WBK CM AJR.

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T cells
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Mycobacterium tuberculosis
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Antigens
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Immune response
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Cytotoxic T cells
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Mouse models
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Tuberculosis
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Animal models of infection
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