About the Authors

Darren Boone

Affiliation Centre for Medical Imaging, University College London, London, United Kingdom

Susan Mallett

Affiliation School of Health and Population Sciences, University of Birmingham, Birmingham, United Kingdom

Justine McQuillan

Affiliation Centre for Medical Imaging, University College London, London, United Kingdom

Stuart A. Taylor

Affiliation Centre for Medical Imaging, University College London, London, United Kingdom

Douglas G. Altman

Affiliation Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom

Steve Halligan

s.halligan@ucl.ac.uk

Affiliation Centre for Medical Imaging, University College London, London, United Kingdom

Competing Interests

The authors have read the journal's policy and the authors of this manuscript have the following competing interests: At the time of writing, SH and SAT have a non-remunerated agreement with iCAD Inc. Nashua, NH, who provide software for research purposes. At the time the data for the present study were collected (2005 to 2010) SH and SAT had remunerated research agreements with Midicsight Inc., a software company that developed CAD for CT colonography, and JMcQ was employed by Medicsight. Medicsight ceased trading in 2011. The other authors declare no current conflicts of interest. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SM JM SAT DGA SH. Performed the experiments: DB SM JM SAT DGA SH. Analyzed the data: SM JM DGA SH. Wrote the paper: DB SM JM SAT DGA SH.