About the Authors

Yosuke Hamamoto

Affiliation Department of Orthopedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

Hiromu Ito

hiromu@kuhp.kyoto-u.ac.jp

Affiliation Department of Orthopedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

Moritoshi Furu

Affiliations Department of Orthopedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan, Department of the Control for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan

Motomu Hashimoto

Affiliation Department of the Control for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan

Takao Fujii

Affiliation Department of the Control for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan

Masahiro Ishikawa

Affiliations Department of Orthopedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan, Department of the Control for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan

Noriyuki Yamakawa

Affiliation Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan

Chikashi Terao

Affiliation Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

Masayuki Azukizawa

Affiliation Department of Orthopedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

Takahiro Iwata

Affiliation Department of Orthopedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

Tsuneyo Mimori

Affiliation Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan

Shuichi Matsuda

Affiliation Department of Orthopedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

Competing Interests

M.F., M.H., M.I., and T.F. belong to the department that is financially supported by 4 pharmaceutical companies (Mitsubishi-Tanabe, Chugai, Bristol-Myers, and Eisai). H.I. has received research grants and/or speaker fees from Chugai, Mitsubishi-Tanabe, Daiichi-Sankyo, Eisai, Bristol-Myers, Abbvie, and Astellas. M.F. and M.I. have received grant and research support from Astellas and Pfizer Japan. T.F. has received grant and research support from Bristol-Myers and Pfizer Japan. Y.H., N.Y., C.T., M.A., T.I, T.M., and S.M. declared no conflict of interest exists. The sponsors were not involved in the study design; in the collection, analysis, interpretation of data; in the writing of this manuscript; or in the decision to submit the article for publication. The authors, their immediate families, and any research foundations with which they are affiliated have not received any financial payments or other benefits from any commercial entity related to the subject of this article. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HI TM SM. Performed the experiments: YH MF MH TF NY. Analyzed the data: YH MF MI CT MA TI. Contributed reagents/materials/analysis tools: CT. Wrote the paper: YH HI.