About the Authors

Hsien-Yi Chiu

Contributed equally to this work with: Hsien-Yi Chiu, Hui-Ling Huang

Affiliations Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan, Department of Dermatology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan, Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan

Hui-Ling Huang

Contributed equally to this work with: Hsien-Yi Chiu, Hui-Ling Huang

Affiliations Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan, Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan

Chien-Hsun Li

Affiliations Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan, Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan

Hung-An Chen

Affiliation Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan

Chia-Lun Yeh

Affiliation Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan

Shih-Hsiang Chiu

Affiliation Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan

Wei-Chun Lin

Affiliation Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan

Yu-Pin Cheng

Affiliation Department of Dermatology, Cathay General Hospital, Taipei, Taiwan

Tsen-Fang Tsai

tftsai@yahoo.com (T-FT); syho@mail.nctu.edu.tw (S-YH)

Affiliation Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

Shinn-Ying Ho

tftsai@yahoo.com (T-FT); syho@mail.nctu.edu.tw (S-YH)

Affiliations Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan, Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan

Competing Interests

Dr. Tsai has conducted clinical trials or received honoraria for serving as a consultant for Pfizer Pharmaceuticals, Serono International SA (now Merck Serono International), UniPharma/Biogen Idec, Novartis Pharmaceuticals and Janssen-Cilag Pharmaceutical and has received speaking fees from AbbVie. Other authors have no conflicts of interest to declare. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HYC HLH CHL YPC TFT SYH. Performed the experiments: HYC HLH CHL HAC CLY SHC WCL YPC TFT SYH. Analyzed the data: HLH HAC CLY SHC WCL SYH. Contributed reagents/materials/analysis tools: HLH CHL HAC CLY SHC WCL YPC SYH. Wrote the paper: HYC HLH CHL HAC CLY SHC WCL YPC TFT SYH.