About the Authors

Eugene Y. H. Tang

e.y.h.tang@newcastle.ac.uk

Affiliation Institute of Health and Society, Newcastle University Institute of Ageing, Newcastle University, Newcastle upon Tyne, NE2 4AX, United Kingdom

Stephanie L. Harrison

Affiliation Institute of Health and Society, Newcastle University Institute of Ageing, Newcastle University, Newcastle upon Tyne, NE2 4AX, United Kingdom

Linda Errington

Affiliation Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom

Mark F. Gordon

Affiliation Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut, 06877, United States of America

Pieter Jelle Visser

Affiliations Maastricht University, Department of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience, Maastricht, The Netherlands, VU University Medical Centre, Department of Neurology, Alzheimer Centre, Neuroscience Campus, Amsterdam, The Netherlands

Gerald Novak

Affiliation Janssen Pharmaceutical Research and Development, 1125 Trenton-Harbourton Road, Titusville, New Jersey, 08560, United States of America

Carole Dufouil

Affiliation Inserm Research Centre (U897), Team Neuroepidemiology, F-33000, Bordeaux, France

Carol Brayne

Affiliation Department of Public Health and Primary Care, Cambridge University, Cambridge, CB2 0SR, United Kingdom

Louise Robinson

Affiliation Institute of Health and Society, Newcastle University Institute of Ageing, Newcastle University, Newcastle upon Tyne, NE2 4AX, United Kingdom

Lenore J. Launer

Affiliation Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health (NIH), Bethesda, Maryland, United States of America

Blossom C. M. Stephan

Affiliation Institute of Health and Society, Newcastle University Institute of Ageing, Newcastle University, Newcastle upon Tyne, NE2 4AX, United Kingdom

Competing Interests

Dr. G. Novak is an employee of Janssen Research and Development, LLC. Dr. M Gordon is an employee of Boehringer Ingelheim Pharmaceuticals. Boehringer Ingelheim Pharmaceuticals and Janssen Research and Development provided support in the form of salaries for authors [G.N., M.G.], but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section.

Author Contributions

Conceived and designed the experiments: EYHT BCMS. Performed the experiments: EYHT SLH LE BCMS. Analyzed the data: EYHT SLH BCMS. Wrote the paper: EYHT SLH MFG PJV GN CD CB LR LJL BCMS.