Different Mechanisms of Regulation of the Warburg Effect in Lymphoblastoid and Burkitt Lymphoma Cells

Muhammad Mushtaq; Suhas Darekar; George Klein; Elena Kashuba

doi:10.1371/journal.pone.0136142

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Open Access

Peer-reviewed

Research Article

Different Mechanisms of Regulation of the Warburg Effect in Lymphoblastoid and Burkitt Lymphoma Cells

Muhammad Mushtaq,

Affiliation Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, Stockholm, Sweden
⨯
Suhas Darekar,

Affiliation Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, Stockholm, Sweden
⨯
George Klein ,

Contributed equally to this work with: George Klein, Elena Kashuba

Affiliation Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, Stockholm, Sweden
⨯
Elena Kashuba

Contributed equally to this work with: George Klein, Elena Kashuba

* E-mail: Elena.Kashuba@ki.se

Affiliations Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, Stockholm, Sweden, R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NASU, Kyiv, Ukraine
⨯

Different Mechanisms of Regulation of the Warburg Effect in Lymphoblastoid and Burkitt Lymphoma Cells

Muhammad Mushtaq,
Suhas Darekar,
George Klein,
Elena Kashuba

Published: August 27, 2015
https://doi.org/10.1371/journal.pone.0136142

About the Authors

Muhammad Mushtaq

Affiliation Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, Stockholm, Sweden

Suhas Darekar

Affiliation Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, Stockholm, Sweden

George Klein

Contributed equally to this work with: George Klein, Elena Kashuba

Affiliation Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, Stockholm, Sweden

Elena Kashuba

Contributed equally to this work with: George Klein, Elena Kashuba

* E-mail: Elena.Kashuba@ki.se

Affiliations Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, Stockholm, Sweden, R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NASU, Kyiv, Ukraine

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EK. Performed the experiments: MM SD EK. Analyzed the data: MM SD GK EK. Contributed reagents/materials/analysis tools: MM SD EK. Wrote the paper: MM GK EK.

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Glycolysis
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Gene expression
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Pyruvate
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Warburg effect
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Cloning
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Raji cells
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Colorimetric assays
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Transcription factors
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