Is Hemoglobin Level in Patients with Nasopharyngeal Carcinoma Still a Significant Prognostic Factor in the Era of Intensity-Modulated Radiotherapy Technology?

Shan-Shan Guo; Lin-Quan Tang; Qiu-Yan Chen; Lu Zhang; Li-Ting Liu; Pei-Yu Huang; Ka-Jia Cao; Ling Guo; Hao-Yuan Mo; Xiang Guo; Ming-Huang Hong; Mu-Sheng Zeng; Chao-Nan Qian; Hai-Qiang Mai

doi:10.1371/journal.pone.0136033

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Open Access

Peer-reviewed

Research Article

Is Hemoglobin Level in Patients with Nasopharyngeal Carcinoma Still a Significant Prognostic Factor in the Era of Intensity-Modulated Radiotherapy Technology?

Shan-Shan Guo ,

Contributed equally to this work with: Shan-Shan Guo, Lin-Quan Tang

Affiliations Sun Yat-sen University Cancer Center;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, P. R. China, Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China
⨯
Lin-Quan Tang ,

Contributed equally to this work with: Shan-Shan Guo, Lin-Quan Tang

Affiliations Sun Yat-sen University Cancer Center;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, P. R. China, Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China
⨯
Qiu-Yan Chen,

Affiliations Sun Yat-sen University Cancer Center;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, P. R. China, Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China
⨯
Lu Zhang,

Affiliations Sun Yat-sen University Cancer Center;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, P. R. China, Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China
⨯
Li-Ting Liu,

Affiliations Sun Yat-sen University Cancer Center;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, P. R. China, Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China
⨯
Pei-Yu Huang,

Affiliations Sun Yat-sen University Cancer Center;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, P. R. China, Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China
⨯
Ka-Jia Cao,

Affiliations Sun Yat-sen University Cancer Center;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, P. R. China, Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China
⨯
Ling Guo,

Affiliations Sun Yat-sen University Cancer Center;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, P. R. China, Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China
⨯
Hao-Yuan Mo,

Affiliations Sun Yat-sen University Cancer Center;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, P. R. China, Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China
⨯
Xiang Guo,

Affiliations Sun Yat-sen University Cancer Center;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, P. R. China, Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China
⨯
Ming-Huang Hong,

Affiliations Sun Yat-sen University Cancer Center;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, P. R. China, GCP Center, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
⨯
Mu-Sheng Zeng,

Affiliation Sun Yat-sen University Cancer Center;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, P. R. China
⨯
Chao-Nan Qian,

Affiliations Sun Yat-sen University Cancer Center;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, P. R. China, Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China
⨯
Hai-Qiang Mai

* E-mail: maihq@sysucc.org.cn

Affiliations Sun Yat-sen University Cancer Center;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, P. R. China, Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China
⨯

Is Hemoglobin Level in Patients with Nasopharyngeal Carcinoma Still a Significant Prognostic Factor in the Era of Intensity-Modulated Radiotherapy Technology?

Shan-Shan Guo,
Lin-Quan Tang,
Qiu-Yan Chen,
Lu Zhang,
Li-Ting Liu,
Pei-Yu Huang,
Ka-Jia Cao,
Ling Guo,
Hao-Yuan Mo,
Xiang Guo

Published: August 27, 2015
https://doi.org/10.1371/journal.pone.0136033

About the Authors

Shan-Shan Guo

Contributed equally to this work with: Shan-Shan Guo, Lin-Quan Tang

Affiliations Sun Yat-sen University Cancer Center;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, P. R. China, Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China

Lin-Quan Tang

Contributed equally to this work with: Shan-Shan Guo, Lin-Quan Tang

Qiu-Yan Chen

Lu Zhang

Li-Ting Liu

Pei-Yu Huang

Ka-Jia Cao

Ling Guo

Hao-Yuan Mo

Xiang Guo

Ming-Huang Hong

Affiliations Sun Yat-sen University Cancer Center;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, P. R. China, GCP Center, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China

Mu-Sheng Zeng

Affiliation Sun Yat-sen University Cancer Center;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, P. R. China

Chao-Nan Qian

Hai-Qiang Mai

* E-mail: maihq@sysucc.org.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: S-SG L-QT H-QM. Performed the experiments: H-QM S-SG L-QT. Analyzed the data: H-QM S-SG L-QT. Contributed reagents/materials/analysis tools: Q-YC LZ L-TL P-YH K-JC LG H-YM XG M-HH M-SZ C-NQ. Wrote the paper: H-QM S-SG L-QT.

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Cancer treatment
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Nasopharyngeal carcinoma
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Anemia
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Hemoglobin
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Radiation therapy
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Head and neck cancers
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