About the Authors

Takahiko Toyonaga

Affiliation Department of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Osaka, Japan

Hiroshi Nakase

hiropy_n@kuhp.kyoto-u.ac.jp

Affiliation Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan

Satoru Ueno

Affiliation Department of Internal medicine, Takashima Municipal Hospital, Takashima, Shiga, Japan

Minoru Matsuura

Affiliation Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan

Takuya Yoshino

Affiliation Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan

Yusuke Honzawa

Affiliation Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan

Ayako Itou

Affiliation Nutritional Science Institute, Morinaga Milk Industry Co., Ltd, Zama, Kanagawa, Japan

Kazuyoshi Namba

Affiliation Nutritional Science Institute, Morinaga Milk Industry Co., Ltd, Zama, Kanagawa, Japan

Naoki Minami

Affiliation Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan

Satoshi Yamada

Affiliation Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan

Yorimitsu Koshikawa

Affiliation Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan

Toshimitsu Uede

Affiliation Department of Matrix Medicine, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan

Tsutomu Chiba

Affiliation Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan

Kazuichi Okazaki

Affiliation Department of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Osaka, Japan

Competing Interests

AI & KN are employees of Morinaga Milk Industry Co., Ltd. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HN TC KO. Performed the experiments: TT SU MM TY YH AI KN NM SY YK. Analyzed the data: TT SU HN. Contributed reagents/materials/analysis tools: TU. Wrote the paper: TT HN.