About the Authors
- Emanuele M. Gargano
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Affiliation Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken, Germany
- Giuseppe Allegretta
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Affiliation Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany
- Enrico Perspicace
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Affiliation Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken, Germany
- Angelo Carotti
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Affiliation Dipartimento Farmaco-Chimico, Università degli Studi di Bari, Bari, Italy
- Chris Van Koppen
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Affiliation ElexoPharm GmbH, Saarbrücken, Germany
- Martin Frotscher
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Affiliation Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken, Germany
- Sandrine Marchais-Oberwinkler
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* E-mail: rolf.hartmann@helmoltz-hzi.de (RWH); s.marchais@mx.uni-saarland.de (SMO)
Affiliations Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken, Germany, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany
- Rolf W. Hartmann
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* E-mail: rolf.hartmann@helmoltz-hzi.de (RWH); s.marchais@mx.uni-saarland.de (SMO)
Affiliations Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken, Germany, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany
Competing Interests
The authors have declared that no competing interests exist. Chris Van Koppen is an employee of Elexopharm GmbH. He was in charge of the biological testing of the compounds. This work was based on a scientific collaboration between Elexopharm GmbH, the Saarland University and the Helmholtz Institute for Pharmaceutical Research Saarland. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials related to this study.
Author Contributions
Conceived and designed the experiments: EMG SMO. Performed the experiments: EMG GA EP CVK. Analyzed the data: EMG SMO. Contributed reagents/materials/analysis tools: EMG EP. Wrote the paper: EMG AC SMO MF RWH.