Lithium Modulates Autophagy in Esophageal and Colorectal Cancer Cells and Enhances the Efficacy of Therapeutic Agents In Vitro and In Vivo

Tracey R. O’Donovan; Simon Rajendran; Seamus O’Reilly; Gerald C. O’Sullivan; Sharon L. McKenna

doi:10.1371/journal.pone.0134676

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Open Access

Peer-reviewed

Research Article

Lithium Modulates Autophagy in Esophageal and Colorectal Cancer Cells and Enhances the Efficacy of Therapeutic Agents In Vitro and In Vivo

Tracey R. O’Donovan,

Affiliation Leslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork, Cork, Ireland
⨯
Simon Rajendran,

Affiliation Leslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork, Cork, Ireland
⨯
Seamus O’Reilly,

Affiliation Department of Medical Oncology, Cork University Hospital, Cork, Ireland
⨯
Gerald C. O’Sullivan †,

† Deceased.

Affiliation Leslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork, Cork, Ireland
⨯
Sharon L. McKenna

* E-mail: s.mckenna@ucc.ie

Affiliation Leslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork, Cork, Ireland
⨯

Lithium Modulates Autophagy in Esophageal and Colorectal Cancer Cells and Enhances the Efficacy of Therapeutic Agents In Vitro and In Vivo

Tracey R. O’Donovan,
Simon Rajendran,
Seamus O’Reilly,
Gerald C. O’Sullivan,
Sharon L. McKenna

Published: August 6, 2015
https://doi.org/10.1371/journal.pone.0134676

About the Authors

Tracey R. O’Donovan

Affiliation Leslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork, Cork, Ireland

Simon Rajendran

Affiliation Leslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork, Cork, Ireland

Seamus O’Reilly

Affiliation Department of Medical Oncology, Cork University Hospital, Cork, Ireland

Gerald C. O’Sullivan

† Deceased.

Affiliation Leslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork, Cork, Ireland

Sharon L. McKenna

* E-mail: s.mckenna@ucc.ie

Affiliation Leslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork, Cork, Ireland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TOD SMCK GCOS. Performed the experiments: TOD SR. Analyzed the data: TOD SMCK SR SOR GCOS. Contributed reagents/materials/analysis tools: TOD SMCK SR SOR GCOS. Wrote the paper: TOD SMCK.

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Lithium
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Autophagic cell death
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Cancer treatment
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Apoptosis
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Colorectal cancer
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Chloroquine
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Lysosomes
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Vesicles
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