Titanium Dioxide Nanoparticles Trigger Loss of Function and Perturbation of Mitochondrial Dynamics in Primary Hepatocytes

Vaishaali Natarajan; Christina L. Wilson; Stephen L. Hayward; Srivatsan Kidambi

doi:10.1371/journal.pone.0134541

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Peer-reviewed

Research Article

Titanium Dioxide Nanoparticles Trigger Loss of Function and Perturbation of Mitochondrial Dynamics in Primary Hepatocytes

Vaishaali Natarajan,

Affiliation Department of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, NE, 68588, United States of America
⨯
Christina L. Wilson,

Affiliation Department of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, NE, 68588, United States of America
⨯
Stephen L. Hayward,

Affiliation Department of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, NE, 68588, United States of America
⨯
Srivatsan Kidambi

* E-mail: skidambi2@unl.edu

Affiliations Department of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, NE, 68588, United States of America, Nebraska Center for Materials and Nanoscience, University of Nebraska-Lincoln, NE, 68588, United States of America, Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, NE, 68198, United States of America
⨯

Titanium Dioxide Nanoparticles Trigger Loss of Function and Perturbation of Mitochondrial Dynamics in Primary Hepatocytes

Vaishaali Natarajan,
Christina L. Wilson,
Stephen L. Hayward,
Srivatsan Kidambi

Published: August 6, 2015
https://doi.org/10.1371/journal.pone.0134541

About the Authors

Vaishaali Natarajan

Affiliation Department of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, NE, 68588, United States of America

Christina L. Wilson

Affiliation Department of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, NE, 68588, United States of America

Stephen L. Hayward

Affiliation Department of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, NE, 68588, United States of America

Srivatsan Kidambi

* E-mail: skidambi2@unl.edu

Affiliations Department of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, NE, 68588, United States of America, Nebraska Center for Materials and Nanoscience, University of Nebraska-Lincoln, NE, 68588, United States of America, Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, NE, 68198, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SK VN. Performed the experiments: VN CLW SLH. Analyzed the data: SK VN CLW SLH. Contributed reagents/materials/analysis tools: SK VN. Wrote the paper: SK VN.

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Nanoparticles
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Hepatocytes
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Mitochondria
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Urea
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Albumins
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Reactive oxygen species
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Oxidative stress
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Cytotoxicity
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