Resistance to Inhibitors of Cholinesterase 3 (Ric-3) Expression Promotes Selective Protein Associations with the Human α7-Nicotinic Acetylcholine Receptor Interactome

Matthew J. Mulcahy; Sydney B. Blattman; Francisco J. Barrantes; Ronald J. Lukas; Edward Hawrot

doi:10.1371/journal.pone.0134409

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Peer-reviewed

Research Article

Resistance to Inhibitors of Cholinesterase 3 (Ric-3) Expression Promotes Selective Protein Associations with the Human α7-Nicotinic Acetylcholine Receptor Interactome

Matthew J. Mulcahy,

Affiliation Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island, United States of America
⨯
Sydney B. Blattman,

Affiliation Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island, United States of America
⨯
Francisco J. Barrantes,

Affiliation Laboratory of Molecular Neurobiology, Institute of Biomedical Research, UCA-CONICET, Buenos Aires, Argentina
⨯
Ronald J. Lukas,

Affiliation Division of Neurobiology, Barrow Neurological Institute, Phoenix, Arizona, United States of America
⨯
Edward Hawrot

* E-mail: Edward_Hawrot@brown.edu

Affiliation Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island, United States of America
⨯

Resistance to Inhibitors of Cholinesterase 3 (Ric-3) Expression Promotes Selective Protein Associations with the Human α7-Nicotinic Acetylcholine Receptor Interactome

Matthew J. Mulcahy,
Sydney B. Blattman,
Francisco J. Barrantes,
Ronald J. Lukas,
Edward Hawrot

Published: August 10, 2015
https://doi.org/10.1371/journal.pone.0134409

About the Authors

Matthew J. Mulcahy

Affiliation Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island, United States of America

Sydney B. Blattman

Affiliation Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island, United States of America

Francisco J. Barrantes

Affiliation Laboratory of Molecular Neurobiology, Institute of Biomedical Research, UCA-CONICET, Buenos Aires, Argentina

Ronald J. Lukas

Affiliation Division of Neurobiology, Barrow Neurological Institute, Phoenix, Arizona, United States of America

Edward Hawrot

* E-mail: Edward_Hawrot@brown.edu

Affiliation Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FJB EH MJM. Performed the experiments: MJM SBB. Analyzed the data: MJM SBB. Contributed reagents/materials/analysis tools: FJB RJL EH. Wrote the paper: MJM SBB FJB RJL EH.

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Cytoskeletal proteins
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Nicotinic acetylcholine receptors
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Membrane proteins
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Chaperone proteins
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Protein expression
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Amino acid analysis
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Intracellular receptors
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Interaction networks
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