About the Authors

Irina Gurt

Affiliation Endocrinology and Metabolism Service, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

Hanna Artsi

Affiliation Endocrinology and Metabolism Service, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

Einav Cohen-Kfir

Current address: Institute of Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

Affiliation Endocrinology and Metabolism Service, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

Gilad Hamdani

Current address: Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America.

Affiliation Endocrinology and Metabolism Service, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

Gal Ben-Shalom

Affiliation Endocrinology and Metabolism Service, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

Ben Feinstein

Affiliation The Einstein Institute of Mathematics; The Hebrew University of Jerusalem, Jerusalem, Israel

Madi El-Haj

Affiliation Department of Orthopedics, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

Rivka Dresner-Pollak

rivkap@hadassah.org.il

Affiliation Endocrinology and Metabolism Service, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

Competing Interests

The authors of this manuscript have no competing interests: Sirtris/GSK provided SRT2183 and SRT3025 for the purposes of this study. The authors' received the compounds free of charge and got no grant support to conduct this study. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: IG RDP. Performed the experiments: IG ECK GH GBS MEH. Analyzed the data: IG HA GH BF RDP. Contributed reagents/materials/analysis tools: IG HA BF. Wrote the paper: IG RDP.