About the Authors
- Joe G. Zein
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Contributed equally to this work with: Joe G. Zein, Serpil C. Erzurum
* E-mail: zeinj@ccf.org
Affiliation Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
- Raed A. Dweik
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¶‡ These authors also contributed equally to this work.
Affiliation Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
- Suzy A. Comhair
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¶‡ These authors also contributed equally to this work.
Affiliation Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio, United States of America
- Eugene R. Bleecker
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¶‡ These authors also contributed equally to this work.
Affiliation Center for Genomics and Personalized Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
- Wendy C. Moore
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¶‡ These authors also contributed equally to this work.
Affiliation Center for Genomics and Personalized Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
- Stephen P. Peters
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¶‡ These authors also contributed equally to this work.
Affiliation Center for Genomics and Personalized Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
- William W. Busse
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¶‡ These authors also contributed equally to this work.
Affiliation Department of Medicine, The University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin, United States of America
- Nizar N. Jarjour
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¶‡ These authors also contributed equally to this work.
Affiliation Department of Medicine, The University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin, United States of America
- William J. Calhoun
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¶‡ These authors also contributed equally to this work.
Affiliation Department of Medicine, University of Texas Medical Branch, Galveston, Texas, United States of America
- Mario Castro
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¶‡ These authors also contributed equally to this work.
Affiliation Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
- K. Fan Chung
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¶‡ These authors also contributed equally to this work.
Affiliation The National Heart and Lung Institute, Imperial College, London, United Kingdom
- Anne Fitzpatrick
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¶‡ These authors also contributed equally to this work.
Affiliation Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America
- Elliot Israel
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¶‡ These authors also contributed equally to this work.
Affiliation Pulmonary Division, Harvard Medical School, Brigham and Women’s Hospital, Boston, Massachussets, United States of America
- W. Gerald Teague
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¶‡ These authors also contributed equally to this work.
Affiliation Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
- Sally E. Wenzel
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¶‡ These authors also contributed equally to this work.
Affiliation Asthma Institute, The University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
- Thomas E. Love
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¶‡ These authors also contributed equally to this work.
Affiliation Department of Epidemiology and Biostatistics, Case Western Reserve University-MetroHealth Medical Center, Cleveland, Ohio, United States of America
- Benjamin M. Gaston
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¶‡ These authors also contributed equally to this work.
Affiliation Department of Pediatric, Rainbow Babies and Children’s Hospital, Cleveland, Ohio, United States of America
- Serpil C. Erzurum
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Contributed equally to this work with: Joe G. Zein, Serpil C. Erzurum
Affiliations Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio, United States of America
- on behalf of The Severe Asthma Research Program
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¶Membership of The Severe Asthma Research Program is provided in the Acknowledgments.
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: SCE JGZ. Performed the experiments: SAC ERB WWB WJC MC KFC RAD AF EI NNJ WCM SPP WGT SEW BMG SCE. Analyzed the data: JGZ SCE SAC. Contributed reagents/materials/analysis tools: SAC ERB WWB WJC MC KFC RAD AF EI NNJ WCM SPP WGT SEW BMG SCE. Wrote the paper: JGZ SCE. Supervised statistical analysis: TEL.