About the Authors

Masamitsu Konno

Affiliation Department of Frontier Science for Cancer and Chemotherapy, Osaka University Graduate School of Medicine, Osaka, 565–0871, Japan

Jun Koseki

Affiliation Department of Cancer Profiling Discovery, Osaka University Graduate School of Medicine, Osaka, 565–0871, Japan

Koichi Kawamoto

Affiliations Department of Frontier Science for Cancer and Chemotherapy, Osaka University Graduate School of Medicine, Osaka, 565–0871, Japan, Department of Gastrointestinal Surgery, Osaka University Graduate School of Medicine, Osaka, 565–0871, Japan

Naohiro Nishida

Affiliation Department of Frontier Science for Cancer and Chemotherapy, Osaka University Graduate School of Medicine, Osaka, 565–0871, Japan

Hidetoshi Matsui

Affiliation Faculty of Science, Kyushu University, Fukuoka, 819–0395, Japan

Dyah Laksmi Dewi

Affiliations Department of Frontier Science for Cancer and Chemotherapy, Osaka University Graduate School of Medicine, Osaka, 565–0871, Japan, Department of Gastrointestinal Surgery, Osaka University Graduate School of Medicine, Osaka, 565–0871, Japan

Miyuki Ozaki

Affiliation Department of Frontier Science for Cancer and Chemotherapy, Osaka University Graduate School of Medicine, Osaka, 565–0871, Japan

Yuko Noguchi

Affiliation Department of Frontier Science for Cancer and Chemotherapy, Osaka University Graduate School of Medicine, Osaka, 565–0871, Japan

Koshi Mimori

Affiliation Kyushu University, Department of Molecular and Surgical Oncology, Tsurumihara 4546, Beppu, Ohita, 874–0838, Japan

Noriko Gotoh

Affiliation Division of Cancer Cell Biology, Cancer Research Institute of Kanazawa University, Kakuma-machi, Kanazawa, 920–1192, Japan

Nobuhiro Tanuma

Affiliation Division of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Natori, 981–1293, Japan

Hiroshi Shima

Affiliation Division of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Natori, 981–1293, Japan

Yuichiro Doki

Affiliations Department of Frontier Science for Cancer and Chemotherapy, Osaka University Graduate School of Medicine, Osaka, 565–0871, Japan, Department of Cancer Profiling Discovery, Osaka University Graduate School of Medicine, Osaka, 565–0871, Japan, Department of Gastrointestinal Surgery, Osaka University Graduate School of Medicine, Osaka, 565–0871, Japan

Masaki Mori

Contributed equally to this work with: Masaki Mori, Hideshi Ishii

hishii@gesurg.med.osaka-u.ac.jp (HI); mmori@gesurg.med.osaka-u.ac.jp (MM)

Affiliations Department of Frontier Science for Cancer and Chemotherapy, Osaka University Graduate School of Medicine, Osaka, 565–0871, Japan, Department of Cancer Profiling Discovery, Osaka University Graduate School of Medicine, Osaka, 565–0871, Japan, Department of Gastrointestinal Surgery, Osaka University Graduate School of Medicine, Osaka, 565–0871, Japan

Hideshi Ishii

Contributed equally to this work with: Masaki Mori, Hideshi Ishii

hishii@gesurg.med.osaka-u.ac.jp (HI); mmori@gesurg.med.osaka-u.ac.jp (MM)

Affiliations Department of Frontier Science for Cancer and Chemotherapy, Osaka University Graduate School of Medicine, Osaka, 565–0871, Japan, Department of Cancer Profiling Discovery, Osaka University Graduate School of Medicine, Osaka, 565–0871, Japan

Competing Interests

The authors have the following interests. Institutional endowments were received partially from Taiho Pharmaceutical Co., Ltd. (http://www.taiho.co.jp/english/), Evidence Based Medical (EBM) Research Center (http://ebmrce.co.jp/index.html), Chugai Co., Ltd. (http://www.chugai-pharm.co.jp/english/index.html), Yakult Honsha Co., Ltd. (http://www.yakult.co.jp/english/index.html), and Merck Co., Ltd. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: MK MM HI. Performed the experiments: MK JK KK NN DLD NT HS. Analyzed the data: MK HM KM NG YD. Contributed reagents/materials/analysis tools: MK MO YN. Wrote the paper: MK MM HI.