About the Authors

Carmen Walter

Affiliation Institute of Clinical Pharmacology, Goethe—University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany

Violeta Dimova

Affiliations Institute of Clinical Pharmacology, Goethe—University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany

Julia Bu

Affiliation Institute of Clinical Pharmacology, Goethe—University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany

Michael J. Parnham

Affiliation Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology TMP, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany

Bruno G. Oertel

Affiliation Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology TMP, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany

Jörn Lötsch

j.loetsch@em.uni-frankfurt.de

Affiliations Institute of Clinical Pharmacology, Goethe—University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology TMP, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JL CW VD BGO. Performed the experiments: CW VD JB. Analyzed the data: JL. Wrote the paper: JL CW VD MJP BGO.