About the Authors

Shunji Kasai

s-kasai@hhc.eisai.co.jp

Affiliation Vitamin E Information and Technology Section, Customer Joy Department, Eisai Co. Ltd., Tokyo, Japan

Akemi Ito

Affiliation Ito Bone Histomorphometry Institute, Niigata, Japan

Kaori Shindo

Affiliation Canon Lifecare Solutions Inc., Tokyo, Japan

Tohru Toyoshi

Affiliation Study Department, Nihon Bioresearch Inc., Gifu, Japan

Masahiro Bando

Affiliation Eisai Product Creation Systems, Eisai Co. Ltd., Tsukuba, Japan

Competing Interests

All authors are employees of Eisai Co. Ltd., Ito Bone Histomorphometry Institute, Canon Lifecare Solutions Inc., or Nihon Bioresearch Inc. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SK. Performed the experiments: AI KS TT. Analyzed the data: MB SK. Wrote the paper: SK.