About the Authors

Lena Winstedt

Affiliation Hansa Medical AB, Scheelevägen 22, P.O. Box 785, SE-22007 Lund, Sweden

Sofia Järnum

Affiliation Hansa Medical AB, Scheelevägen 22, P.O. Box 785, SE-22007 Lund, Sweden

Emma Andersson Nordahl

Affiliation Hansa Medical AB, Scheelevägen 22, P.O. Box 785, SE-22007 Lund, Sweden

Andreas Olsson

Affiliation Hansa Medical AB, Scheelevägen 22, P.O. Box 785, SE-22007 Lund, Sweden

Anna Runström

Affiliation Hansa Medical AB, Scheelevägen 22, P.O. Box 785, SE-22007 Lund, Sweden

Robert Bockermann

Affiliation Hansa Medical AB, Scheelevägen 22, P.O. Box 785, SE-22007 Lund, Sweden

Christofer Karlsson

Affiliation Department of Clinical Sciences, Lund, Lund University, SE-221 84 Lund, Sweden

Johan Malmström

Affiliation Department of Clinical Sciences, Lund, Lund University, SE-221 84 Lund, Sweden

Gabriella Samuelsson Palmgren

Affiliation Clinical Trials Unit, Skåne University Hospital, Lund, Sweden

Ulf Malmqvist

Affiliation Clinical Trials Unit, Skåne University Hospital, Lund, Sweden

Lars Björck

christian.kjellman@hansamedical.com (CK); lars.bjorck@med.lu.se (LB)

Affiliation Department of Clinical Sciences, Lund, Lund University, SE-221 84 Lund, Sweden

Christian Kjellman

christian.kjellman@hansamedical.com (CK); lars.bjorck@med.lu.se (LB)

Affiliation Hansa Medical AB, Scheelevägen 22, P.O. Box 785, SE-22007 Lund, Sweden

Competing Interests

have read the journal's policy and the authors of this manuscript have the following competing interests: Hansa Medical AB was the formal sponsor and funder of the clinical trial. LW, SJ, EAN, AO, AR, RB, and CK are employed by Hansa Medical AB. LB is an inventor on patent applications related to IdeS and owns shares in Hansa Medical AB. The patent applications are: 1. International publication No: WO/2006/131347 Title: USE OF THE IDES PROTEINASE (FROM S. PYOGENES) FOR TREATING AUTOIMMUNE DISEASES AND GRAFT REJECTION International publication date: 14.12.2006 2. International publication No: WO/2003/051914 Title: IDES, AN IGG-DEGRADING ENZYME OF STREPTOCOCCUS PYOGENES International publication date: 26.06.2003 This does not alter our adherence to PLOS ONE policy on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LW SJ JM UM CKj. Performed the experiments: SJ EAN AO AR RB CKa GSP. Analyzed the data: LW SJ CKa CKj. Wrote the paper: LW SJ EAN CKa LB CKj.