About the Authors

Yonghui Jin

Contributed equally to this work with: Yonghui Jin, Hassan Elalaf

Affiliation Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

Hassan Elalaf

Contributed equally to this work with: Yonghui Jin, Hassan Elalaf

Affiliation Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

Makoto Watanabe

Affiliations Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan, Life Science Research Center, Shimadzu Cooperation, Kyoto, Japan

Sakura Tamaki

Affiliation Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

Sho Hineno

Affiliation Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

Kazuhito Matsunaga

Affiliations Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan, Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan, Department of Gastroenterology and Hepatology, Graduate School of Medicine, Yamaguchi University, Ube, Japan

Knut Woltjen

Affiliation Department of Reprogramming Sciences, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan

Yukiko Kobayashi

Affiliation Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

Sanae Nagata

Affiliation Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan

Makoto Ikeya

Affiliation Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan

Tomohisa Kato Jr

Affiliation Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

Takeshi Okamoto

Affiliation Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Shuichi Matsuda

Affiliation Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Junya Toguchida

togjun@frontier.kyoto-u.ac.jp

Affiliations Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan, Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan, Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Competing Interests

One of the co-authors, Makoto Watanabe, is an employee of Shimadzu Cooperation. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YJ HE JT. Performed the experiments: YJ HE MW YK SN MI. Analyzed the data: YJ HE MW JT. Contributed reagents/materials/analysis tools: ST SH KM KW TK TO SM. Wrote the paper: YJ HE JT.